SCHEMBL8657237

SCHEMBL8657237

Cc1cc(NC(=O)NC(=O)c2c(F)cccc2F)c(C)c(Cl)c1Oc1ccc(Oc2ccc(Cl)cc2Cl)c(C(C)C)c1

nearest known ligand 0.42

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
USP2 O75604 1/20 0.42
MAPT P10636 1/20 0.42
ALOX15 P16050 1/20 0.42
NPSR1 Q6W5P4 1/20 0.39
THRB P10828 3/20 0.38
THRA P10827 2/20 0.38
POLB P06746 1/20 0.36
PNLIP P16233 2/20 0.36
RORC P51449 4/20 0.36
GCGR P47871 1/20 0.35
LPAR1 Q92633 2/20 0.35
ATM Q13315 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9134173 0.93 NPSR1 (0.40) MAPTNPSR1THRBTHRAPOLB
SCHEMBL8089012 0.88 MEN1 (0.51) MEN1KMT2AUSP2MAPTALOX15
SCHEMBL9135134 0.88 MEN1 (0.46) MEN1KMT2AUSP2MAPTALOX15
SCHEMBL8660804 0.84 GCGR (0.52) NPSR1PNLIPGCGR
SCHEMBL10495943 0.84 MEN1 (0.52) MEN1KMT2AUSP2MAPTALOX15
SCHEMBL8658874 0.83 MEN1 (0.51) MEN1KMT2AUSP2MAPTALOX15
SCHEMBL8661504 0.83 MEN1 (0.45) MEN1KMT2AUSP2MAPTALOX15
SCHEMBL8660930 0.82 MEN1 (0.49) MEN1KMT2AUSP2MAPTALOX15
SCHEMBL8660795 0.82 MEN1 (0.49) MEN1KMT2AUSP2MAPTALOX15
SCHEMBL8662536 0.82 KMT2A (0.49) MEN1KMT2AUSP2MAPTALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5776981-A Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals NOVARTIS CORPORATION (US) 1998-07-07 US disclosed
US-5776982-A Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals NOVARTIS CORPORATION (US) 1998-07-07 US disclosed
US-5420163-A Insecticides or miticides CIBA-GEIGY (US) 1995-05-30 US disclosed
US-5135953-A Oral or injections; cattle, swine, poultry CIBA-GEIGY (US) 1992-08-04 US disclosed
EP-0211004-A1 USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS RHONE-POULENC NEDERLAND B.V. (NL) 1987-02-25 EP disclosed
US-4602109-A Novel pesticidal phenoxyphenyl and phenoxypyridyl benzoyl ureas and process for preparation UNION CARBIDE CORPORATION (US) 1986-07-22 US disclosed
WO-1986003941-A1 USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS UNION CARBIDE CORPORATION (US) 1986-07-17 WO disclosed
US-4540578-A Pesticidal phenoxypyridyl benzoyl ureas UNION CARBIDE CORPORATION (US) 1985-09-10 US disclosed
EP-0113247-A1 Pesticidal phenoxyphenyl and phenoxypyridyl benzoyl ureas and process for their preparation UNION CARBIDE CORPORATION (US) 1984-07-11 EP disclosed