SCHEMBL8657271

SCHEMBL8657271

O=S(=O)(Nc1ccccc1-c1ccc(F)cc1)c1ccccc1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
STAT3 P40763 2/20 0.72
MCOLN3 Q8TDD5 2/20 0.63
LMNA P02545 2/20 0.63
CA12 O43570 1/20 0.63
CA2 P00918 1/20 0.63
CA9 Q16790 1/20 0.63
MEN1 O00255 1/20 0.58
TSHR P16473 1/20 0.58
KMT2A Q03164 1/20 0.58
KEAP1 Q14145 1/20 0.57
NFE2L2 Q16236 1/20 0.57
ALDH1A1 P00352 2/20 0.55
L3MBTL1 Q9Y468 2/20 0.55
MAPT P10636 2/20 0.53
GAA P10253 1/20 0.53
ALOX5AP P20292 1/20 0.53
FEN1 P39748 1/20 0.53
USP2 O75604 1/20 0.53
POLB P06746 1/20 0.53
CYP2C9 P11712 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5410713 0.88 MCOLN3 (0.78) STAT3MCOLN3LMNACA12CA2
SCHEMBL8661642 0.86 MCOLN3 (0.57) STAT3MCOLN3LMNACA12CA2
SCHEMBL8661273 0.84 MCOLN3 (0.63) STAT3MCOLN3LMNACA12CA2
SCHEMBL8659813 0.84 LMNA (0.88) STAT3MCOLN3LMNACA12CA2
SCHEMBL8661304 0.84 MCOLN3 (0.63) STAT3MCOLN3LMNACA12CA2
SCHEMBL8657373 0.84 LMNA (0.63) STAT3MCOLN3LMNACA12CA2
SCHEMBL8658522 0.83 STAT3 (0.74) STAT3MCOLN3LMNACA12CA2
SCHEMBL8659831 0.83 LMNA (0.61) STAT3MCOLN3LMNACA12CA2
SCHEMBL8661265 0.83 STAT3 (0.53) STAT3MEN1TSHRKMT2AKEAP1
SCHEMBL8661932 0.83 MCOLN3 (0.58) STAT3MCOLN3LMNACA12CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5739166-A ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT G.D. SEARLE & CO. (US) 1998-04-14 US claimed
US-5739166-A ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT G.D. SEARLE & CO. (US) 1998-04-14 US disclosed
EP-0794942-A1 SUBSTITUTED BIPHENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1997-09-17 EP disclosed
WO-1996016934-A1 SUBSTITUTED BIPHENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1996-06-06 WO disclosed