SCHEMBL8657367

SCHEMBL8657367

Cc1ccccc1Oc1c(C)cc(NC(=O)NC(=O)c2c(F)cccc2F)c(C)c1Cl

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.51
MEN1 O00255 4/20 0.51
MAPT P10636 2/20 0.45
USP2 O75604 1/20 0.45
ALOX15 P16050 1/20 0.45
ATM Q13315 2/20 0.43
POLB P06746 1/20 0.41
KDM4E B2RXH2 1/20 0.41
GAA P10253 1/20 0.41
THRB P10828 1/20 0.41
RECQL P46063 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
PYGL P06737 3/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
RAB9A P51151 1/20 0.37
SCN8A Q9UQD0 1/20 0.36
SCN10A Q9Y5Y9 1/20 0.36
MET P08581 2/20 0.36
GCK P35557 1/20 0.36
PPIA P62937 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8659795 0.90 KMT2A (0.49) KMT2AMEN1MAPTUSP2ALOX15
SCHEMBL8660930 0.90 MEN1 (0.49) KMT2AMEN1MAPTUSP2ALOX15
SCHEMBL8658960 0.90 KMT2A (0.49) KMT2AMEN1MAPTUSP2ALOX15
SCHEMBL8657343 0.90 KMT2A (0.49) KMT2AMEN1MAPTUSP2ALOX15
SCHEMBL8665574 0.90 KMT2A (0.51) KMT2AMEN1MAPTUSP2ALOX15
SCHEMBL8657533 0.90 ATM (0.43) KMT2AMEN1MAPTUSP2ALOX15
SCHEMBL8660974 0.89 KMT2A (0.47) KMT2AMEN1MAPTUSP2ALOX15
SCHEMBL9134437 0.89 KMT2A (0.49) KMT2AMEN1MAPTUSP2ALOX15
SCHEMBL8658869 0.89 KMT2A (0.51) KMT2AMEN1MAPTUSP2ALOX15
SCHEMBL8659428 0.89 KMT2A (0.53) KMT2AMEN1MAPTUSP2ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5776981-A Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals NOVARTIS CORPORATION (US) 1998-07-07 US disclosed
US-5776982-A Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals NOVARTIS CORPORATION (US) 1998-07-07 US disclosed
US-5420163-A Insecticides or miticides CIBA-GEIGY (US) 1995-05-30 US disclosed
US-5135953-A Oral or injections; cattle, swine, poultry CIBA-GEIGY (US) 1992-08-04 US disclosed
US-4873264-A Novel pesticidal 1-(alkyl-phenoxy-aryl)-3-benzoyl ureas and process for preparation RHONE-POULENC NEDERLANDS B.V. (NL) 1989-10-10 US disclosed
EP-0098158-B1 PESTICIDAL 1-(ALKYL-PHENOXYARYL)-3-BENZOYL UREAS AND PROCESS FOR PREPARATION UNION CARBIDE CORPORATION (US) 1987-11-19 EP disclosed
EP-0211004-A1 USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS RHONE-POULENC NEDERLAND B.V. (NL) 1987-02-25 EP disclosed
WO-1986003941-A1 USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS UNION CARBIDE CORPORATION (US) 1986-07-17 WO disclosed
EP-0124283-A1 Process for the preparation of benzoyl ureas UNION CARBIDE CORPORATION (US) 1984-11-07 EP disclosed
US-4450307-A Hydroxy-containing bicycloalkane ether compounds TEXACO INC. (US) 1984-05-22 US disclosed
EP-0098158-A1 Pesticidal 1-(alkyl-phenoxyaryl)-3-benzoyl ureas and process for preparation UNION CARBIDE CORPORATION (US) 1984-01-11 EP disclosed