SCHEMBL8658403

SCHEMBL8658403

ClC(Cl)=CCOc1cc(Cl)c(OCCc2ccccc2Cl)c(Cl)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIRT2 Q8IXJ6 1/20 0.38
TAAR1 Q96RJ0 3/20 0.35
HTT P42858 1/20 0.35
SLC6A2 P23975 1/20 0.34
SLC6A4 P31645 1/20 0.34
SLC6A3 Q01959 1/20 0.34
NR4A2 P43354 2/20 0.33
HTR3E A5X5Y0 1/20 0.33
HTR3B O95264 1/20 0.33
HTR3A P46098 1/20 0.33
HTR3D Q70Z44 1/20 0.33
HTR3C Q8WXA8 1/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
HTR2A P28223 1/20 0.32
HTR2C P28335 1/20 0.32
HTR2B P41595 1/20 0.32
MAOB P27338 2/20 0.32
MAPT P10636 2/20 0.32
HPGD P15428 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8654811 0.87 AKR1B1 (0.36) HTTNPC1RAB9AMAPT
SCHEMBL8405491 0.86 NR4A2 (0.43) HTTNR4A2NPC1RAB9AMAOB
SCHEMBL8654720 0.86 SIRT2 (0.39) SIRT2MAOBMAOA
SCHEMBL8519414 0.85 HPGD (0.38) HTTNPC1RAB9AMAOBHPGD
SCHEMBL8657700 0.82 HTT (0.40) TAAR1HTTNPC1RAB9APLAU
SCHEMBL2444928 0.82 HTT (0.37) HTTPLAU
SCHEMBL8660296 0.82 HPGD (0.39) MAOBHPGDL3MBTL1MAOA
SCHEMBL8408794 0.81 HTT (0.39) HTTMAPTHPGDMAPK1L3MBTL1
SCHEMBL8408754 0.81 HTT (0.39) HTTMAPTHPGDMAPK1L3MBTL1
SCHEMBL8408702 0.81 KCNA3 (0.41) TAAR1HTTNPC1RAB9AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0722430-B1 DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL CO (JP) 1998-10-21 EP disclosed
EP-0722430-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1996-07-24 EP disclosed
WO-1996004228-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-02-15 WO disclosed