SCHEMBL8658642

SCHEMBL8658642

ClC(Cl)=CCOc1cc(Br)c(OCCc2ccc(Br)cc2)c(Br)c1

nearest known ligand 0.41

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 8/20 0.41
MAOA P21397 2/20 0.41
MAOB P27338 2/20 0.41
RHEB Q15382 2/20 0.38
HTT P42858 1/20 0.35
PPARA Q07869 3/20 0.34
SIRT2 Q8IXJ6 1/20 0.34
FFAR1 O14842 1/20 0.33
FFAR4 Q5NUL3 1/20 0.33
SLC2A1 P11166 1/20 0.32
PPARG P37231 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8409332 0.90 PPARD (0.40) PPARDMAOAMAOBRHEBHTT
SCHEMBL8657194 0.84 PPARD (0.37) PPARDMAOAMAOBHTTPPARA
SCHEMBL8837934 0.84 MAOA (0.42) PPARDMAOAMAOBRHEBPPARA
SCHEMBL8658506 0.83 IGF1R (0.38) PPARDMAOAMAOBRHEBHTT
SCHEMBL8659951 0.83 PPARD (0.39) PPARDMAOAMAOBRHEBHTT
SCHEMBL8657406 0.82 RHEB (0.43) MAOAMAOBRHEBFFAR1
SCHEMBL8405833 0.80 KLK1 (0.38) HTT
SCHEMBL7977649 0.79 KLK1 (0.37) HTT
SCHEMBL8405448 0.79 KLK1 (0.41) HTT
SCHEMBL8405839 0.79 KLK1 (0.37) HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0722430-B1 DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL CO (JP) 1998-10-21 EP disclosed
EP-0722430-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1996-07-24 EP disclosed
WO-1996004228-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-02-15 WO disclosed