SCHEMBL8658648

SCHEMBL8658648

FC(F)(F)c1ccc(CCOc2c(Cl)cc(OCC=C(Cl)Cl)cc2Cl)cc1

nearest known ligand 0.37

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PTGES O14684 3/20 0.37
ALOX5 P09917 3/20 0.37
PPARG P37231 2/20 0.37
FFAR1 O14842 1/20 0.37
PPARA Q07869 3/20 0.36
PPARD Q03181 2/20 0.36
SIRT2 Q8IXJ6 1/20 0.36
THRB P10828 1/20 0.35
MAOB P27338 1/20 0.35
PSEN1 P49768 1/20 0.35
CYP19A1 P11511 1/20 0.34
CYP11B1 P15538 1/20 0.34
CYP11B2 P19099 1/20 0.34
TAAR1 Q96RJ0 1/20 0.34
GPR84 Q9NQS5 1/20 0.34
RORC P51449 1/20 0.33
NMT1 P30419 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8659996 0.94 FFAR1 (0.36) PTGESALOX5PPARGFFAR1PPARA
SCHEMBL8655461 0.93 HDAC1 (0.36) PTGESALOX5PPARGFFAR1PPARA
SCHEMBL8408840 0.88 MAOB (0.42) PPARGPPARAPPARDMAOB
SCHEMBL8657189 0.88 PPARA (0.38) PPARGPPARAPPARDSIRT2MAOB
SCHEMBL8408308 0.87 TAAR1 (0.40) ALOX5FFAR1SIRT2THRBMAOB
SCHEMBL8661564 0.87 RORC (0.39) ALOX5PPARGFFAR1PPARAPPARD
SCHEMBL8405597 0.87 MAOB (0.39) FFAR1PPARAPPARDTHRBMAOB
SCHEMBL8405535 0.87 PPARA (0.39) FFAR1PPARAPPARDTHRBMAOB
SCHEMBL8518771 0.86 MAOB (0.38) PPARGPPARAPPARDSIRT2MAOB
SCHEMBL6549944 0.84 HTT (0.34) PPARGPPARAPPARDRORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0722430-B1 DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL CO (JP) 1998-10-21 EP disclosed