SCHEMBL8658987

SCHEMBL8658987

Fc1ccc(CCCCOc2c(Cl)cc(OCC=C(Cl)Cl)cc2Cl)cc1

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 10/20 0.39
PPARG P37231 3/20 0.39
PPARD Q03181 7/20 0.33
HTT P42858 1/20 0.33
MAOB P27338 2/20 0.32
CNR1 P21554 1/20 0.32
CNR2 P34972 1/20 0.32
S1PR1 P21453 1/20 0.32
S1PR3 Q99500 1/20 0.32
MAOA P21397 1/20 0.32
SLC2A1 P11166 1/20 0.31
MEN1 O00255 1/20 0.31
MAPT P10636 1/20 0.31
KMT2A Q03164 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8659980 0.96 PPARA (0.39) PPARAPPARGPPARDHTTMAOB
SCHEMBL8657189 0.94 PPARA (0.38) PPARAPPARGPPARDHTTMAOB
SCHEMBL8408013 0.90 IGF1R (0.39) PPARAPPARGHTTMAOBS1PR1
SCHEMBL8405678 0.88 S1PR1 (0.41) MAOBS1PR1S1PR3MAOAMEN1
SCHEMBL8405813 0.87 SCN8A (0.36) MAOBMAOA
SCHEMBL8655461 0.87 HDAC1 (0.36) PPARAPPARGPPARDMAOBMEN1
SCHEMBL8658519 0.86 S1PR1 (0.41) CNR1CNR2S1PR1S1PR3
SCHEMBL8661920 0.86 S1PR1 (0.41) CNR1CNR2S1PR1S1PR3
SCHEMBL8519267 0.86 FFAR4 (0.38) PPARAPPARGPPARDHTTMAOB
SCHEMBL8657375 0.86 PPARA (0.41) PPARAPPARGPPARDHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0722430-B1 DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL CO (JP) 1998-10-21 EP disclosed
EP-0722430-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1996-07-24 EP disclosed
WO-1996004228-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-02-15 WO disclosed