Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 5/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PRNP | P04156 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8657232 | 0.79 | AKR1A1 (0.51) | AKR1B1 | |
| SCHEMBL8660253 | 0.79 | AKR1A1 (0.51) | AKR1B1 | |
| SCHEMBL8655720 | 0.77 | AKR1A1 (0.52) | AKR1B1 | |
| SCHEMBL8858934 | 0.77 | AKR1B1 (0.43) | HTTSMN1; SMN2AKR1B1HDAC6MAPT | |
| SCHEMBL8858946 | 0.75 | AKR1B1 (0.42) | ALOX15HTTSMN1; SMN2AKR1B1HDAC6 | |
| SCHEMBL8858937 | 0.73 | AKR1B1 (0.47) | SMN1; SMN2AKR1B1MAPTALDH1A1LMNA | |
| SCHEMBL8655865 | 0.73 | AKR1A1 (0.53) | AKR1B1 | |
| SCHEMBL8400340 | 0.72 | AKR1B1 (0.46) | ALOX15HTTSMN1; SMN2AKR1B1MAPT | |
| SCHEMBL24331734 | 0.72 | AKR1B1 (0.52) | ALOX15HTTSMN1; SMN2AKR1B1HDAC6 | |
| SCHEMBL7835431 | 0.72 | SMN1; SMN2 (0.89) | ALOX15HTTSMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714893-B1 | 2-substituted benzothiazole derivatives useful in the treatment of diabetic complications | GRELAN PHARMACEUTICAL CO (JP) | 1998-10-21 | — | — | EP | disclosed |
| US-5700819-A | ALDOSE REDUCTASE ENZYME INHIBITOR | GRELAN PHARMACEUTICAL CO., LTD. (JP) | 1997-12-23 | — | — | US | disclosed |
| EP-0714893-A1 | 2-substituted benzothiazole derivatives useful in the treatment of diabetic complications | GRELAN PHARMACEUTICAL CO., LTD. (JP) | 1996-06-05 | — | — | EP | disclosed |