Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 13/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 12/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 11/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27614352 | 0.81 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL27482339 | 0.81 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| Butane SCHEMBL8660047 | 0.79 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL28707357 | 0.79 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| Butane SCHEMBL8660131 | 0.78 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| Butane SCHEMBL8658759 | 0.77 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL8660080 | 0.77 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL7460548 | 0.75 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL28330863 | 0.74 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| Ammonia Solution, Strong SCHEMBL8660128 | 0.73 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728686-A | TREATMENT OF MUSCULAR DYSTROPHY | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-17 | — | — | US | disclosed |