Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.49 |
| ▸ | ALOX5AP | P20292 | 6/20 | 0.43 |
| ▸ | FEN1 | P39748 | 6/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8661284 | 0.91 | PTGS2 (0.49) | PTGS2PTGS1ALOX5APFEN1 | |
| SCHEMBL8662931 | 0.90 | ALOX5AP (0.47) | PTGS2PTGS1ALOX5APFEN1 | |
| SCHEMBL8660245 | 0.89 | PTGS2 (0.50) | PTGS2PTGS1ALOX5APFEN1 | |
| SCHEMBL8659078 | 0.87 | PTGS2 (0.66) | PTGS2PTGS1ALOX5APFEN1 | |
| SCHEMBL8659788 | 0.87 | PTGS2 (0.66) | PTGS2PTGS1ALOX5APFEN1 | |
| SCHEMBL8661194 | 0.87 | PTGS2 (0.50) | PTGS2PTGS1ALOX5APFEN1 | |
| SCHEMBL8659292 | 0.87 | PTGS2 (0.45) | PTGS2PTGS1ALOX5APFEN1CA12 | |
| SCHEMBL8661297 | 0.87 | PTGS2 (0.49) | PTGS2PTGS1ALOX5APFEN1 | |
| SCHEMBL8659136 | 0.86 | CA1 (0.44) | PTGS2PTGS1ALOX5APFEN1CA12 | |
| SCHEMBL8661274 | 0.86 | PTGS2 (0.50) | PTGS2PTGS1ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | claimed |
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | disclosed |