Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 7/20 | 0.50 |
| ▸ | FEN1 | P39748 | 7/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.49 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA4 | P22748 | 2/20 | 0.39 |
| ▸ | CA6 | P23280 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8660206 | 0.91 | ALOX5AP (0.48) | ALOX5APFEN1PTGS2PTGS1PTGES2 | |
| SCHEMBL8659220 | 0.89 | ALOX5AP (0.51) | ALOX5APFEN1PTGS2PTGS1PTGES2 | |
| SCHEMBL8658337 | 0.86 | PTGS2 (0.56) | ALOX5APFEN1PTGS2PTGS1PTGES2 | |
| SCHEMBL8656801 | 0.86 | ALOX5AP (0.49) | ALOX5APFEN1PTGS2PTGS1F10 | |
| SCHEMBL8662888 | 0.86 | PTGS2 (0.51) | ALOX5APFEN1PTGS2PTGS1PTGES2 | |
| SCHEMBL8661067 | 0.85 | PTGES2 (0.48) | ALOX5APFEN1PTGS2PTGS1PTGES2 | |
| SCHEMBL8658525 | 0.84 | ALOX5AP (0.57) | ALOX5APFEN1PTGS2PTGS1F10 | |
| SCHEMBL8658017 | 0.83 | PTGS1 (0.49) | ALOX5APFEN1PTGS2PTGS1PTGES2 | |
| SCHEMBL8661644 | 0.83 | PTGS1 (0.49) | ALOX5APFEN1PTGS2PTGS1PTGES2 | |
| SCHEMBL8663422 | 0.83 | PTGS2 (0.72) | ALOX5APFEN1PTGS2PTGS1PTGES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | disclosed |