SCHEMBL8660271

SCHEMBL8660271

CCCC1(CC(=O)OC)CCCCC1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.37
LMNA P02545 2/20 0.37
ALDH1A1 P00352 2/20 0.37
USP2 O75604 1/20 0.37
CYP1A2 P05177 1/20 0.37
BLM P54132 1/20 0.37
CACNA2D1 P54289 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
CYP3A4 P08684 2/20 0.35
TP53 P04637 1/20 0.35
CYP4F2 P78329 1/20 0.35
CYP4A11 Q02928 1/20 0.35
CETP P11597 1/20 0.34
NPSR1 Q6W5P4 1/20 0.33
CYP2C19 P33261 1/20 0.33
HSD17B10 Q99714 1/20 0.32
MGAM O43451 1/20 0.32
GAA P10253 1/20 0.32
SI P14410 1/20 0.32
MGAM2 Q2M2H8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4691009 0.86 TSHR (0.43) TSHRLMNAALDH1A1USP2CYP1A2
SCHEMBL28122667 0.85 CYP4F2 (0.40) TSHRCYP4F2CYP4A11CETP
SCHEMBL4691370 0.83 TSHR (0.36) TSHRLMNAALDH1A1USP2CYP1A2
SCHEMBL4691239 0.81 TP53 (0.35) TSHRLMNAALDH1A1USP2CYP1A2
SCHEMBL13980754 0.80 TSHR (0.34) TSHRLMNAALDH1A1USP2CYP1A2
SCHEMBL8286058 0.80 TSHR (0.39) TSHRLMNAALDH1A1USP2CYP1A2
SCHEMBL11937857 0.80 ALDH1A1 (0.59) TSHRLMNAALDH1A1USP2CYP1A2
SCHEMBL3819838 0.78 ALDH1A1 (0.57) TSHRLMNAALDH1A1USP2CYP1A2
SCHEMBL4691068 0.78 ALDH1A1 (0.57) TSHRLMNAALDH1A1USP2CYP1A2
SCHEMBL466314 0.78 TSHR (0.62) TSHRLMNAALDH1A1USP2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5830911-A ANTIARTHRITIC AGENTS; ANTICARCINOGENIC AGENTS; ALZHEIMER'SDISEASE AMERICAN HOME PRODUCTS CORPORATION (US) 1998-11-03 US disclosed