Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8660042 | 0.90 | HPGD (0.53) | MCL1HPGDLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL8659966 | 0.89 | HPGD (0.59) | HPGDLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL8659289 | 0.88 | LMNA (0.54) | MCL1HPGDLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL8658030 | 0.86 | HPGD (0.51) | HPGDLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL8662810 | 0.86 | HPGD (0.51) | HPGDLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL8659094 | 0.86 | HPGD (0.51) | MCL1HPGDLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL8661509 | 0.85 | HPGD (0.53) | HPGDLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL8663502 | 0.85 | PTGES2 (0.51) | HPGDALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL8659193 | 0.83 | HPGD (0.48) | MCL1HPGDLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL8661655 | 0.83 | HPGD (0.48) | MCL1HPGDLMNAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | disclosed |