Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.62 |
| ▸ | FABP4 | P15090 | 3/20 | 0.62 |
| ▸ | FABP3 | P05413 | 2/20 | 0.62 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28440969 | 0.98 | KDM4E (0.61) | KDM4EFABP4FABP3FFAR4LMNA | |
| SCHEMBL8353116 | 0.98 | KDM4E (0.61) | KDM4EFABP4FABP3FFAR4LMNA | |
| SCHEMBL28439445 | 0.95 | FFAR4 (0.67) | KDM4EFABP4FABP3FFAR4LMNA | |
| SCHEMBL15522001 | 0.86 | TP53 (0.71) | KDM4ELMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL7036402 | 0.84 | HDAC2 (0.63) | KDM4ELMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL19458668 | 0.84 | KDM4E (0.60) | KDM4ELMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL8148742 | 0.84 | LMNA (0.62) | FABP4FABP3LMNAALDH1A1KMT2A | |
| SCHEMBL8151680 | 0.84 | LMNA (0.62) | FABP4FABP3LMNAALDH1A1KMT2A | |
| SCHEMBL8162525 | 0.84 | LMNA (0.62) | FABP4FABP3LMNAALDH1A1KMT2A | |
| SCHEMBL8161670 | 0.84 | LMNA (0.62) | FABP4FABP3LMNAALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874808-A1 | BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | Abbott Laboratories (US) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997018188-A1 | BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LABORATORIES (US) | 1997-05-22 | — | — | WO | disclosed |