Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 18/20 | 0.58 |
| ▸ | HTR1B | P28222 | 18/20 | 0.58 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL8659656 | 0.96 | HTR1D (0.54) | HTR1DHTR1BPIM1 | |
| SCHEMBL7471152 | 0.85 | HTR1D (0.73) | HTR1DHTR1BHTR1A | |
| SCHEMBL8664693 | 0.85 | HTR1D (0.72) | HTR1DHTR1B | |
| SCHEMBL8662842 | 0.85 | HTR1D (0.53) | HTR1DHTR1BPIM1HTR1A | |
| Oxalic Acid SCHEMBL8660714 | 0.81 | HTR1D (0.67) | HTR1DHTR1B | |
| SCHEMBL7482425 | 0.80 | HTR1D (0.68) | HTR1DHTR1BHTR1A | |
| SCHEMBL8805866 | 0.79 | HTR1D (0.63) | HTR1DHTR1BHTR1A | |
| SCHEMBL8662360 | 0.78 | HTR1D (0.42) | HTR1DHTR1BHTR1A | |
| SCHEMBL8471026 | 0.74 | HTR1A (0.82) | HTR1DHTR1BHTR1A | |
| SCHEMBL7474143 | 0.73 | HTR1D (1.00) | HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0759918-A1 | PIPERAZINE, PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES OF INDOL-3-YLALKYL AS 5-HT1D-ALPHA AGONISTS | MERCK SHARP & DOHME LTD. (GB) | 1997-03-05 | — | — | EP | claimed |
| WO-1995032196-A1 | PIPERAZINE, PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES OF INDOL-3-YLALKYL AS 5-HT1D-ALPHA AGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1995-11-30 | — | — | WO | claimed |
| US-5807857-A | Piperazine, piperidine and tetrahydropyridine derivative of indol-3-alkyl as 5-HT1D-α agonists | MERCK SHARP & DOHME LTD. (GB) | 1998-09-15 | — | — | US | disclosed |
| EP-0759918-A1 | PIPERAZINE, PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES OF INDOL-3-YLALKYL AS 5-HT1D-ALPHA AGONISTS | MERCK SHARP & DOHME LTD. (GB) | 1997-03-05 | — | — | EP | disclosed |
| WO-1995032196-A1 | PIPERAZINE, PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES OF INDOL-3-YLALKYL AS 5-HT1D-ALPHA AGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1995-11-30 | — | — | WO | disclosed |