Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 7/20 | 0.48 |
| ▸ | FEN1 | P39748 | 7/20 | 0.48 |
| ▸ | CA1 | P00915 | 4/20 | 0.42 |
| ▸ | CA2 | P00918 | 4/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.38 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.38 |
| ▸ | F10 | P00742 | 3/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8661455 | 0.91 | ALOX5AP (0.46) | ALOX5APFEN1CA1CA2CA9 | |
| SCHEMBL8657869 | 0.90 | ALOX5AP (0.45) | ALOX5APFEN1CA1CA2CA9 | |
| SCHEMBL8661401 | 0.88 | ALOX5AP (0.49) | ALOX5APFEN1PTGS2PTGS1F10 | |
| SCHEMBL8660185 | 0.88 | PTGES2 (0.44) | ALOX5APFEN1CA1CA2CA9 | |
| SCHEMBL8661060 | 0.88 | ALOX5AP (0.44) | ALOX5APFEN1CA1CA2CA9 | |
| SCHEMBL8657561 | 0.87 | PTGS1 (0.43) | ALOX5APFEN1CA1CA2PTGS2 | |
| SCHEMBL8660193 | 0.86 | PTGS2 (0.44) | ALOX5APFEN1PTGS2PTGES2PTGS1 | |
| SCHEMBL8659726 | 0.86 | ALOX5AP (0.46) | ALOX5APFEN1CA1CA2CA9 | |
| SCHEMBL8663491 | 0.85 | ALOX5AP (0.41) | ALOX5APFEN1CA1CA2CA9 | |
| SCHEMBL8660480 | 0.85 | ALOX5AP (0.41) | ALOX5APFEN1CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739166-A | ALKYLSULFONYL OR AMINOSULFONYL SUBSTITUTED AROMATIC COMPOUNDS AS NON-STEROIDAL ANTIINFLAMMATORY AGENT | G.D. SEARLE & CO. (US) | 1998-04-14 | — | — | US | disclosed |