SCHEMBL8661106

SCHEMBL8661106

O=C(NC(=O)c1ccccc1Cl)Nc1ccc(Oc2ccc(S(=O)(=O)c3ccc(C(F)(F)F)cc3Cl)cc2)c(Cl)c1

nearest known ligand 0.64

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
GCGR P47871 1/20 0.64
PNLIP P16233 7/20 0.52
TDP1 Q9NUW8 1/20 0.50
STK39 Q9UEW8 1/20 0.45
HSD11B1 P28845 1/20 0.44
AVPR2 P30518 1/20 0.44
GPR27 Q9NS67 1/20 0.44
ABCC9 O60706 1/20 0.44
ABCC8 Q09428 1/20 0.44
KCNJ11 Q14654 1/20 0.44
KCNJ8 Q15842 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8658845 0.91 GCGR (0.50) GCGRPNLIPSTK39HSD11B1
SCHEMBL8662614 0.88 TLR8 (0.47) GCGRPNLIPSTK39HSD11B1
SCHEMBL8659897 0.88 GCGR (0.72) GCGRPNLIPTDP1STK39
SCHEMBL8661111 0.86 TDP1 (0.58) GCGRTDP1AVPR2GPR27
SCHEMBL9325879 0.86 GCGR (0.69) GCGRPNLIPTDP1STK39
SCHEMBL8662539 0.82 GCGR (0.65) GCGRPNLIPTDP1STK39
SCHEMBL8656697 0.81 GCGR (0.68) GCGRPNLIPTDP1STK39
SCHEMBL8658021 0.80 GCGR (0.60) GCGRPNLIPTDP1STK39
SCHEMBL8658911 0.80 TLR8 (0.46) PNLIPSTK39HSD11B1
SCHEMBL11303176 0.80 GCGR (0.59) GCGRPNLIPTDP1STK39

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5776981-A Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals NOVARTIS CORPORATION (US) 1998-07-07 US disclosed
US-5776982-A Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals NOVARTIS CORPORATION (US) 1998-07-07 US disclosed
US-5420163-A Insecticides or miticides CIBA-GEIGY (US) 1995-05-30 US disclosed
US-5135953-A Oral or injections; cattle, swine, poultry CIBA-GEIGY (US) 1992-08-04 US disclosed
EP-0211004-A1 USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS RHONE-POULENC NEDERLAND B.V. (NL) 1987-02-25 EP disclosed
US-4602109-A Novel pesticidal phenoxyphenyl and phenoxypyridyl benzoyl ureas and process for preparation UNION CARBIDE CORPORATION (US) 1986-07-22 US disclosed
WO-1986003941-A1 USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS UNION CARBIDE CORPORATION (US) 1986-07-17 WO disclosed
EP-0113247-B1 PESTICIDAL PHENOXYPHENYL AND PHENOXYPYRIDYL BENZOYL UREAS AND PROCESS FOR THEIR PREPARATION UNION CARBIDE CORPORATION (US) 1986-06-11 EP disclosed
US-4540578-A Pesticidal phenoxypyridyl benzoyl ureas UNION CARBIDE CORPORATION (US) 1985-09-10 US disclosed
EP-0113247-A1 Pesticidal phenoxyphenyl and phenoxypyridyl benzoyl ureas and process for their preparation UNION CARBIDE CORPORATION (US) 1984-07-11 EP disclosed