Genkwanin

Genkwanin

SCHEMBL866123

COc1cc(O)c2c(=O)cc(-c3ccc(O)cc3)oc2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FLT3 P36888 5/20 1.00
IP6K2 Q9UHH9 4/20 1.00
MKNK2 Q9HBH9 3/20 1.00
MAOB P27338 3/20 0.89
CYP19A1 P11511 2/20 0.89
MAPT P10636 10/20 0.82
CYP3A4 P08684 7/20 0.82
CYP2C9 P11712 6/20 0.82
CYP2C19 P33261 6/20 0.82
NPC1 O15118 5/20 0.82
TSHR P16473 3/20 0.82
ABCB1 P08183 2/20 0.82
ABCG2 Q9UNQ0 2/20 0.82
MEN1 O00255 8/20 0.80
KMT2A Q03164 8/20 0.80
ALDH1A1 P00352 5/20 0.80
TP53 P04637 5/20 0.80
CYP2D6 P10635 5/20 0.80
MAPK1 P28482 4/20 0.80
CYP1B1 Q16678 4/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Genkwanin SCHEMBL29445006 1.00 FLT3 (1.00) FLT3IP6K2MKNK2MAOBCYP19A1
Apigenin Dimethylether SCHEMBL29392759 0.94 MAOB (1.00) FLT3IP6K2MKNK2MAOBCYP19A1
Apigenin Dimethylether SCHEMBL1176691 0.94 MAOB (1.00) FLT3IP6K2MKNK2MAOBCYP19A1
Techtochrysin SCHEMBL29494561 0.90 MAPT (1.00) FLT3IP6K2MKNK2MAOBCYP19A1
Techtochrysin SCHEMBL249043 0.90 MAPT (1.00) FLT3IP6K2MKNK2MAOBCYP19A1
SCHEMBL311530 0.89 ABCB1 (0.82) FLT3IP6K2MKNK2MAOBCYP19A1
SCHEMBL29978577 0.89 ABCB1 (0.82) FLT3IP6K2MKNK2MAOBCYP19A1
SCHEMBL30074462 0.89 PLG (1.00) FLT3IP6K2MKNK2MAOBCYP19A1
SCHEMBL4203893 0.89 PLG (1.00) FLT3IP6K2MKNK2MAOBCYP19A1
Acacetin SCHEMBL107712 0.89 CYP1B1 (1.00) FLT3IP6K2MKNK2MAOBCYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1296 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3539550-B1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING NEURODEGENERATIVE DISEASES WHICH INCLUDES FLOWER EXTRACT OF DAPHNE GENKWA AS ACTIVE INGREDIENT KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR) 2026-03-04 EP claimed
CN-121575069-A Application of glycosyltransferase or mutant thereof in biosynthesis of flavone 5-O glycoside 湖北中医药大学 2026-02-27 CN claimed
EP-4698662-A2 REGULATABLE CONTROLLED EXPRESSION OF A TRANSGENE IN PRIMATES AskBio Inc. (US) 2026-02-25 EP claimed
EP-4615506-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES Sahin, Fikret (TR) 2025-09-17 EP claimed
CN-120078850-A Sargentodoxa cuneata-herba patriniae extract, and pharmaceutical composition and application thereof 扬州大学 2025-06-03 CN claimed
CN-119925341-A Application of genkwanin in preparation of antidepressant drugs 郑州大学第一附属医院 2025-05-06 CN claimed
CN-119818477-A Application of genkwanin in preparing medicament for treating diabetic ulcer 上海市皮肤病医院 2025-04-15 CN claimed
WO-2024220449-A9 REGULATABLE CONTROLLED EXPRESSION OF A TRANSGENE IN PRIMATES AskBio Inc. (US) 2025-04-03 WO claimed
EP-4520348-A1 CARBON CHAIN SUBSTANCE FOR REGULATING TRANSMEMBRANE TRANSPORT AND FLUIDITY OF CELL MEMBRANES, AND PREPARATION AND USE THEREOF Sunforest (Beijing) Biopharma Ltd (CN) 2025-03-12 EP claimed
EP-4518685-A1 METHOD OF PREVENTING AND/OR INHIBITING THE OUTGROWTH, SPORULATION, GERMINATION OR TOXIN FORMATION OF CLOSTRIDIUM Givaudan SA (CH) 2025-03-12 EP claimed
US-6872771-B1 Tire with rubber containing flavone THE GOODYEAR TIRE & RUBBER COMPANY (US) 2005-03-29 US claimed
CN-1572755-A Cherry leaf extract and its preparation method ZHENG YUAN (CN) 2005-02-02 CN claimed
US-20030166583-A1 Such as epicatechin coadministered with retinoic acid; bioavailability HU, OLIVER YOA-PU (TW) 2003-09-04 US claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 EP claimed
EP-0290442-A4 PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS. CHEMEX PHARMACEUTICALS INC (US) 1990-07-03 EP claimed
EP-0290442-A1 PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS CHEMEX PHARMACEUTICALS, INC. (US) 1988-11-17 EP claimed
US-4774229-A ANTITUMOR AGENTS, SKIN DISORDERS, CANCER TREATMENT CHEMEX PHARMACEUTICALS, INC. (US) 1988-09-27 US claimed
WO-1988003805-A1 PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS CHEMEX PHARMACEUTICALS, INC. (US) 1988-06-02 WO claimed
WO-1987006833-A1 MODIFICATION OF PLANT EXTRACTS FROM ZYGOPHYLLACEAE CHEMEX PHARMACEUTICALS, INC. (US) 1987-11-19 WO claimed
US-4617293-A Flavonoid phosphate salts of aminoglycoside antibiotics MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 1986-10-14 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030166583-A1 Such as epicatechin coadministered with retinoic acid; bioavailability CYP51A1, CYP2E1, CYP7A1 FLT3 3141/4885IP6K2 4110/4885MKNK2 3164/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.