Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 5/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | CA3 | P07451 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CA6 | P23280 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzidine SCHEMBL28915545 | 0.87 | CYP3A4 (0.69) | MEN1MAPTKMT2ALOXL2CYP3A4 | |
| 4-Aminophenol SCHEMBL28330028 | 0.84 | ALDH1A1 (0.77) | MEN1MAPTKMT2ALOXL2CYP3A4 | |
| SCHEMBL11123599 | 0.82 | CA12 (0.53) | MEN1MAPTKMT2ALOXL2CYP3A4 | |
| Propylamine SCHEMBL10791074 | 0.82 | MAPT (0.53) | MEN1MAPTKMT2ALOXL2CYP3A4 | |
| Aniline SCHEMBL28156835 | 0.82 | TSHR (0.73) | MEN1MAPTKMT2ALOXL2CYP3A4 | |
| SCHEMBL320609 | 0.82 | MEN1 (1.00) | MEN1MAPTKMT2ALOXL2CYP3A4 | |
| SCHEMBL27981 | 0.82 | — | — | |
| SCHEMBL143553 | 0.79 | GFER (0.77) | KMT2ALOXL2CYP3A4TDP1ALDH1A1 | |
| SCHEMBL23916317 | 0.78 | MAPK1 (0.48) | MEN1MAPTKMT2ALOXL2CYP3A4 | |
| SCHEMBL7866458 | 0.78 | TAAR1 (0.62) | MAPTKMT2ATDP1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115895258-B | Polythioether sealant and synthesis method thereof | 中国航发北京航空材料研究院 | 2024-06-18 | — | — | CN | disclosed |
| EP-0724568-B1 | AMIDO PEROXYCARBOXYLIC ACIDS FOR BLEACHING | UNILEVER PLC (GB) | 1998-11-04 | — | — | EP | disclosed |
| US-4990405-A | High strength; waterproofing; gasket seals; dielectrics; dielectrics; papers, films, boards and laminates; construction materials | ARMSTRONG WORLD INDUSTRIES, INC. (US) | 1991-02-05 | — | — | US | disclosed |
| US-4371533-A | ANTITUMOR, ANTIPROTOZOA AND ANTIFUNGAL AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1983-02-01 | — | — | US | disclosed |
| EP-0049528-A1 | 4,5-Deoxymaytansinoids, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1982-04-14 | — | — | EP | disclosed |