Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.78 |
| ▸ | PLK1 | P53350 | 1/20 | 0.61 |
| ▸ | KDR | P35968 | 8/20 | 0.61 |
| ▸ | AURKA | O14965 | 4/20 | 0.61 |
| ▸ | MET | P08581 | 4/20 | 0.61 |
| ▸ | TEK | Q02763 | 4/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31613073 | 0.88 | MTNR1A (1.00) | MTNR1APLK1KDRAURKAMET | |
| SCHEMBL2237855 | 0.84 | MTNR1A (0.56) | MTNR1AKDRAURKAMETTEK | |
| SCHEMBL5774867 | 0.83 | KDR (0.83) | KDRAURKAMETTEKAURKB | |
| SCHEMBL2510203 | 0.83 | CDC25B (0.64) | MTNR1AKDRAURKAMETTEK | |
| SCHEMBL9747620 | 0.83 | MTNR1A (0.55) | MTNR1AKDRAURKAMETTEK | |
| SCHEMBL31613816 | 0.83 | CDC25B (0.64) | MTNR1AKDRAURKAMETTEK | |
| SCHEMBL7108672 | 0.82 | MTNR1A (0.58) | MTNR1AKDRAURKAMETTEK | |
| SCHEMBL31613069 | 0.81 | KDR (0.67) | MTNR1AKDRAURKAMETTEK | |
| SCHEMBL2509951 | 0.81 | MTNR1A (0.52) | MTNR1AKDRAURKAMETTEK | |
| Hydrochloric Acid SCHEMBL7107874 | 0.81 | MTNR1A (0.56) | MTNR1AKDRAURKAMETTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5776984-A | NAPTHYL DERIVATIVES OF BENZENESULFONAMIDES | ABBOTT LABORATORIES (US) | 1998-07-07 | — | — | US | disclosed |
| US-5681842-A | Prostaglandin synthase-2 inhibitors | ABBOTT LABORATORIES (US) | 1997-10-28 | — | — | US | disclosed |