SCHEMBL8662006

SCHEMBL8662006

Nc1nc2c(sc(=O)n2[C@@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]1

nearest known ligand 0.59

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 20/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10183080 1.00 TLR7 (0.59) TLR7
SCHEMBL6972897 1.00 TLR7 (0.59) TLR7
SCHEMBL8662002 1.00 TLR7 (0.59) TLR7
SCHEMBL6984564 1.00 TLR7 (0.59) TLR7
SCHEMBL10147982 0.87 TLR7 (0.47) TLR7
SCHEMBL6972908 0.87 TLR7 (0.47) TLR7
SCHEMBL19774512 0.83 ADRB1 (0.44) TLR7
SCHEMBL14394142 0.83 ADRB1 (0.44) TLR7
SCHEMBL14646808 0.83 ADRB1 (0.44) TLR7
SCHEMBL16016450 0.82 TLR7 (0.43) TLR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0636372-B1 Antiviral, antitumor, antimetastatic, immune system enhancing 7-thia-guanosine derivatives ICN PHARMACEUTICALS (US) 1998-12-02 EP disclosed
EP-0348446-B1 ANTIVIRAL ANTITUMOR ANTIMETASTATIC IMMUNE SYSTEM ENHANCING NUCLEOSIDES AND NUCLEOTIDES UNIV BRIGHAM YOUNG (US) 1995-08-09 EP disclosed
EP-0636372-A1 Antiviral, antitumor, antimetastatic, immune system enhancing 7-thia-guanosine derivatives BRIGHAM YOUNG UNIVERSITY (US) 1995-02-01 EP disclosed
EP-0348446-A4 ANTIVIRAL ANTITUMOR ANTIMETASTATIC IMMUNE SYSTEM ENHANCING NUCLEOSIDES AND NUCLEOTIDES 1991-09-25 EP disclosed
US-5041426-A Viricides, antitumor agents BRIGHAM YOUNG UNIVERSITY (US) 1991-08-20 US disclosed
EP-0348446-A1 ANTIVIRAL ANTITUMOR ANTIMETASTATIC IMMUNE SYSTEM ENHANCING NUCLEOSIDES AND NUCLEOTIDES. UNIV BRIGHAM YOUNG (US) 1990-01-03 EP disclosed
WO-1989005649-A1 ANTIVIRAL ANTITUMOR ANTIMETASTATIC IMMUNE SYSTEM ENHANCING NUCLEOSIDES AND NUCLEOTIDES BRIGHAM YOUNG UNIVERSITY (US) 1989-06-29 WO disclosed