Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.50 |
| ▸ | PPARA | Q07869 | 3/20 | 0.50 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 2/20 | 0.48 |
| ▸ | RXRB | P28702 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.43 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.43 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8669614 | 0.89 | PPARG (0.52) | PPARGPPARACTSKHDAC8HDAC2 | |
| SCHEMBL10722124 | 0.81 | PPARG (0.72) | PPARGPPARAHDAC1 | |
| SCHEMBL7787176 | 0.76 | ALDH1A1 (0.61) | — | |
| SCHEMBL7787613 | 0.75 | HDAC2 (0.43) | PPARGPPARACTSKHDAC8HDAC2 | |
| SCHEMBL4529074 | 0.74 | HDAC8 (0.46) | RXRARXRBHDAC8HDAC2HDAC3 | |
| SCHEMBL6024266 | 0.74 | PPARG (0.47) | PPARGPPARA | |
| SCHEMBL6746224 | 0.74 | PPARG (0.54) | PPARGPPARAHDAC8 | |
| SCHEMBL6298075 | 0.74 | PPARG (0.54) | PPARGPPARAHDAC8 | |
| SCHEMBL6841959 | 0.74 | PPARG (0.54) | PPARGPPARAHDAC8 | |
| SCHEMBL1258205 | 0.73 | CYP2D6 (0.49) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874808-A1 | BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | Abbott Laboratories (US) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997018188-A1 | BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LABORATORIES (US) | 1997-05-22 | — | — | WO | disclosed |