Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.34 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 3/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.32 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.32 |
| ▸ | PRKX | P51817 | 1/20 | 0.32 |
| ▸ | NEK4 | P51957 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8662959 | 1.00 | TAAR1 (0.35) | TAAR1LMNAHTTSMN1; SMN2CYP3A4 | |
| SCHEMBL8663744 | 1.00 | TAAR1 (0.35) | TAAR1LMNAHTTSMN1; SMN2CYP3A4 | |
| SCHEMBL8587279 | 0.85 | HTT (0.37) | TAAR1LMNAHTTSMN1; SMN2CYP3A4 | |
| SCHEMBL8582578 | 0.85 | HTT (0.37) | TAAR1LMNAHTTSMN1; SMN2CYP3A4 | |
| SCHEMBL8582583 | 0.85 | HTT (0.37) | TAAR1LMNAHTTSMN1; SMN2CYP3A4 | |
| SCHEMBL8663786 | 0.82 | SNCA (0.33) | — | |
| SCHEMBL16974831 | 0.80 | ALDH1A1 (0.33) | SMN1; SMN2CYP3A4ALDH1A1 | |
| SCHEMBL8663935 | 0.80 | SNCA (0.32) | — | |
| SCHEMBL7069716 | 0.79 | KDM4C (0.43) | CYP3A4CYP2C9GAAROCK1AURKB | |
| SCHEMBL7068588 | 0.79 | KDM4C (0.43) | CYP3A4CYP2C9GAAROCK1AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906297-A1 | 1,2,4-BENZOTHIADIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997049692-A1 | 1,2,4-BENZOTHIADIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-12-31 | — | — | WO | disclosed |