Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GLS | O94925 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4710194 | 0.80 | SMN1; SMN2 (0.58) | NPC1RAB9ASMN1; SMN2KMT2APOLB | |
| SCHEMBL4710453 | 0.76 | SMN1; SMN2 (0.69) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL8662613 | 0.76 | POLB (0.72) | NPC1RAB9ASMN1; SMN2KMT2APOLB | |
| SCHEMBL12182431 | 0.74 | MAPK1 (0.65) | NPC1RAB9ASMN1; SMN2MAPK1LMNA | |
| SCHEMBL27366586 | 0.73 | SMN1; SMN2 (0.55) | NPC1RAB9ASMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL8797441 | 0.72 | MAPK1 (0.63) | NPC1RAB9ASMN1; SMN2MAPK1LMNA | |
| SCHEMBL22281653 | 0.72 | MAPK1 (0.63) | NPC1RAB9ASMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL7160018 | 0.71 | POLB (0.50) | NPC1RAB9ASMN1; SMN2KMT2APOLB | |
| SCHEMBL9665242 | 0.71 | MAPK1 (0.70) | NPC1RAB9ASMN1; SMN2MAPK1LMNA | |
| SCHEMBL27540728 | 0.70 | MAPK1 (0.50) | NPC1RAB9ASMN1; SMN2KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1053904-C | Novel N-pyridyl carboxamides and derivatives, processes for their preparation and the pharmaceutical compositions which contain them | ADIR (FR) | 2000-06-28 | — | — | CN | claimed |
| US-5712294-A | N-pyridyl carboxamides and derivatives | ADIR ET COMPAGNIE (FR) | 1998-01-27 | — | — | US | claimed |
| EP-0684241-B1 | N-pyridyl carboxamide derivatives, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1997-08-27 | — | — | EP | claimed |
| CN-1121074-A | Novel N-pyridyl carboxamides and derivatives, processes for their preparation and the pharmaceutical compositions which contain them | ADIR (FR) | 1996-04-24 | — | — | CN | claimed |
| EP-0684241-A1 | N-pyridyl carboxamide derivatives, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-11-29 | — | — | EP | claimed |
| CN-1053904-C | Novel N-pyridyl carboxamides and derivatives, processes for their preparation and the pharmaceutical compositions which contain them | ADIR (FR) | 2000-06-28 | — | — | CN | disclosed |
| US-5843947-A | N-pyridyl carboxamides and derivatives | ADIR ET COMPAGNIE (FR) | 1998-12-01 | — | — | US | disclosed |
| US-5712294-A | N-pyridyl carboxamides and derivatives | ADIR ET COMPAGNIE (FR) | 1998-01-27 | — | — | US | disclosed |
| EP-0684241-B1 | N-pyridyl carboxamide derivatives, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1997-08-27 | — | — | EP | disclosed |
| CN-1121074-A | Novel N-pyridyl carboxamides and derivatives, processes for their preparation and the pharmaceutical compositions which contain them | ADIR (FR) | 1996-04-24 | — | — | CN | disclosed |
| EP-0684241-A1 | N-pyridyl carboxamide derivatives, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-11-29 | — | — | EP | disclosed |