Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.54 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 8/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8376598 | 0.87 | TOP2A (0.51) | TOP2APTPN11MAPTHTR3AKDM4E | |
| SCHEMBL2954779 | 0.86 | TOP2A (0.70) | TOP2AMAPTTP53THRBHTR3A | |
| SCHEMBL205172 | 0.82 | PTPN11 (0.62) | PTPN11MAPTTP53KDM4EALDH1A1 | |
| SCHEMBL5619558 | 0.81 | TOP2A (0.52) | TOP2APTPN11MAPTHTR3AKDM4E | |
| SCHEMBL8664917 | 0.81 | TOP2A (0.64) | TOP2AMAPTTP53THRBHTR3A | |
| SCHEMBL17929353 | 0.81 | TOP2A (0.81) | TOP2AMAPTTP53THRBHTR3A | |
| SCHEMBL2957072 | 0.77 | TOP2A (0.59) | TOP2AMAPTTP53THRBHTR3A | |
| SCHEMBL206174 | 0.76 | TOP2A (0.72) | TOP2AMAPTTP53THRBHTR3A | |
| SCHEMBL7434524 | 0.76 | TOP2A (0.88) | TOP2AMAPTTP53HTR3AKDM4E | |
| SCHEMBL1387272 | 0.75 | PARP1 (0.58) | TOP2AMAPTTP53HTR3AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0879820-A1 | Benzamide analogues, useful as PARP (ADP-Ribosyltransferase, ADPRT) DNA repair enzyme inhibitors | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 1998-11-25 | — | — | EP | disclosed |