SCHEMBL8665103

SCHEMBL8665103

C=CCOC(=O)c1ccccc1C(=O)c1ccc(C(=O)O)cc1

nearest known ligand 0.71

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.71
ALDH1A1 P00352 6/20 0.57
TSHR P16473 1/20 0.57
HSD17B10 Q99714 1/20 0.57
L3MBTL1 Q9Y468 2/20 0.48
CYP2C9 P11712 2/20 0.48
CYP1A2 P05177 1/20 0.48
CYP2C19 P33261 1/20 0.48
NPSR1 Q6W5P4 1/20 0.48
AKR1C3 P42330 3/20 0.46
CDC25B P30305 1/20 0.45
ATM Q13315 1/20 0.45
SRD5A2 P31213 1/20 0.44
LMNA P02545 3/20 0.44
NR4A1 P22736 1/20 0.44
CYP2C8 P10632 1/20 0.44
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
THRB P10828 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Terephthalic Acid SCHEMBL27490081 0.94 CYP3A4 (0.80) CYP3A4ALDH1A1TSHRHSD17B10L3MBTL1
SCHEMBL253535 0.92 CYP3A4 (0.77) CYP3A4ALDH1A1TSHRHSD17B10L3MBTL1
SCHEMBL8665105 0.88 CYP3A4 (0.61) CYP3A4ALDH1A1TSHRHSD17B10L3MBTL1
SCHEMBL11125722 0.87 CYP3A4 (0.69) CYP3A4ALDH1A1TSHRHSD17B10L3MBTL1
SCHEMBL11485979 0.87 CYP3A4 (0.69) CYP3A4ALDH1A1TSHRHSD17B10L3MBTL1
SCHEMBL8666516 0.86 CYP3A4 (0.77) CYP3A4ALDH1A1TSHRHSD17B10L3MBTL1
Phthalic Acid SCHEMBL23929049 0.84 CYP3A4 (0.86) CYP3A4ALDH1A1TSHRHSD17B10L3MBTL1
Phthalic Acid SCHEMBL710707 0.84 CYP3A4 (0.86) CYP3A4ALDH1A1TSHRHSD17B10L3MBTL1
Benzene SCHEMBL7689916 0.84 CYP3A4 (0.86) CYP3A4ALDH1A1TSHRHSD17B10L3MBTL1
SCHEMBL87635 0.84 CYP3A4 (0.86) CYP3A4ALDH1A1TSHRHSD17B10L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0880503-A1 BALANOL ANALOGUES Phytera Symbion ApS (DK) 1998-12-02 EP disclosed
WO-1997029091-A1 BALANOL ANALOGUES PHYTERA SYMBION APS (DK) 1997-08-14 WO disclosed