Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8667445 | 0.84 | TSHR (0.39) | TSHRPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL8665677 | 0.84 | TSHR (0.39) | TSHRPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL8667439 | 0.84 | TSHR (0.39) | TSHRPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL27530166 | 0.82 | TSHR (0.38) | TSHRPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL773100 | 0.82 | TSHR (0.47) | TSHRPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL11404100 | 0.80 | TSHR (0.50) | TSHRPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL8667437 | 0.80 | PDGFRB (0.38) | TSHRPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL8667434 | 0.80 | PDGFRB (0.38) | TSHRPDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL7792924 | 0.79 | SLC9A1 (0.45) | — | |
| SCHEMBL8665703 | 0.78 | PDGFRB (0.47) | TSHRPDGFRBFGFR1PDGFRAFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1063438-C | Alkenyl-benzoyl guanidine derivant | MERCK PATENT GMBH (DE) | 2001-03-21 | — | — | CN | disclosed |
| US-5731351-A | Alkenyl-benzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-03-24 | — | — | US | disclosed |
| CN-1150947-A | Alkenyl-benzoyl guanidine derivant | MERCK PATENT GMBH (DE) | 1997-06-04 | — | — | CN | disclosed |