Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TXNRD1 | Q16881 | 4/20 | 0.41 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9500853 | 0.83 | POLB (0.42) | CA12CA9TSHRPOLBSMN1; SMN2 | |
| SCHEMBL9657624 | 0.82 | ALDH1A1 (0.42) | CA12CA9TSHRPOLBSMN1; SMN2 | |
| SCHEMBL11440376 | 0.81 | S1PR3 (0.42) | TXNRD1GSRTHRBCA2 | |
| SCHEMBL23748711 | 0.81 | CA12 (0.51) | CA12CA9TSHREPHX2SMN1; SMN2 | |
| SCHEMBL8982627 | 0.80 | CA12 (0.61) | CA12CA9TSHREPHX2SMN1; SMN2 | |
| SCHEMBL10692989 | 0.80 | CA12 (0.50) | CA12CA9EPHX2THRB | |
| SCHEMBL9619019 | 0.80 | CA12 (0.50) | CA12CA9TSHREPHX2SMN1; SMN2 | |
| SCHEMBL11311354 | 0.77 | S1PR3 (0.45) | TXNRD1GSRTHRB | |
| SCHEMBL16993597 | 0.77 | TSHR (0.50) | CA12CA9TSHRPOLBSMN1; SMN2 | |
| SCHEMBL16993599 | 0.77 | TSHR (0.50) | CA12CA9TSHRPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |