Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 14/20 | 0.77 |
| ▸ | KCNH2 | Q12809 | 13/20 | 0.77 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.68 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.67 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2731306 | 0.88 | KCNJ1 (1.00) | KCNJ1KCNH2HRH3SIGMAR1MAOA | |
| SCHEMBL27555522 | 0.87 | KCNJ1 (0.75) | KCNJ1KCNH2HRH3SIGMAR1MAOA | |
| SCHEMBL8509511 | 0.86 | KCNJ1 (0.77) | KCNJ1KCNH2HRH3SIGMAR1HTR2A | |
| SCHEMBL8715859 | 0.86 | KCNJ1 (0.77) | KCNJ1KCNH2HRH3SIGMAR1HTR2A | |
| SCHEMBL6416345 | 0.85 | KDM4E (0.71) | KCNJ1 | |
| SCHEMBL4717096 | 0.84 | SIGMAR1 (0.71) | KCNJ1KCNH2SIGMAR1HTR2A | |
| SCHEMBL286800 | 0.84 | KCNJ1 (0.84) | KCNJ1KCNH2HRH3SIGMAR1MAOA | |
| SCHEMBL17444701 | 0.83 | KCNH2 (0.73) | KCNJ1KCNH2HRH3SIGMAR1HTR2A | |
| SCHEMBL3526680 | 0.82 | KCNJ1 (0.87) | KCNJ1KCNH2HRH3SIGMAR1MAOA | |
| SCHEMBL5653299 | 0.82 | HRH3 (0.93) | KCNJ1KCNH2HRH3SIGMAR1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880512-A1 | NOVEL AROMATIC PIPERAZINES DERIVED FROM SUBSTITUTED CYCLOAZANES, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS DRUGS | PIERRE FABRE MEDICAMENT (FR) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028141-A1 | NOVEL AROMATIC PIPERAZINES DERIVED FROM SUBSTITUTED CYCLOAZANES, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS DRUGS | PIERRE FABRE MEDICAMENT (FR) | 1997-08-07 | — | — | WO | disclosed |