SCHEMBL8666342

SCHEMBL8666342

CC1(C)CC=C(c2cccs2)c2cc(-c3cccc(C(=O)O)c3NC=O)ccc21

nearest known ligand 0.54

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
RARB P10826 18/20 0.54
RARA P10276 17/20 0.54
RARG P13631 16/20 0.53
RXRA P19793 1/20 0.40
NR2E1 Q9Y466 1/20 0.40
FTO Q9C0B1 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8664217 0.86 RARB (0.42) RARBRARARARGRXRANR2E1
SCHEMBL8661085 0.85 RARB (0.46) RARBRARARARGRXRANR2E1
SCHEMBL8667334 0.85 RARB (0.38) RARBRARARARGRXRANR2E1
SCHEMBL8596916 0.83 RARA (0.57) RARBRARARARGRXRANR2E1
SCHEMBL8661311 0.83 RARB (0.43) RARBRARARARGRXRANR2E1
SCHEMBL8665967 0.82 RARB (0.42) RARBRARARARGRXRANR2E1
SCHEMBL8661417 0.81 RARB (0.43) RARBRARARARGRXRANR2E1
SCHEMBL8667411 0.81 RARB (0.43) RARBRARARARGRXRANR2E1
SCHEMBL8664891 0.80 RARB (0.39) RARBRARARARGRXRANR2E1
SCHEMBL8663812 0.79 RARB (0.40) RARBRARARARGRXRANR2E1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5849923-A Heterocyclic-substituted naphthalenyl retinobenzoic acid derivatives BRISTOL-MYERS SQUIBB COMPANY (US) 1998-12-15 US disclosed