Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.53 |
| ▸ | MET | P08581 | 2/20 | 0.49 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.43 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29161070 | 0.87 | HTR1A (0.55) | HTR1AADRA1DADRA1AADRA1BMET | |
| SCHEMBL8079709 | 0.86 | FERMT2 (0.58) | HTR1AADRA1DADRA1AADRA1BMET | |
| SCHEMBL7105353 | 0.81 | HTR1A (0.56) | HTR1AADRA1DADRA1AADRA1BMET | |
| SCHEMBL10175202 | 0.79 | HTR1A (0.60) | HTR1AADRA1DADRA1AADRA1BMET | |
| SCHEMBL24010334 | 0.77 | HTR1A (0.59) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL30682081 | 0.77 | HTR1A (0.59) | HTR1AADRA1DADRA1AADRA1BMET | |
| SCHEMBL7034663 | 0.77 | HTR1A (0.52) | HTR1AADRA1DADRA1AADRA1BMET | |
| SCHEMBL8079725 | 0.76 | MEN1 (0.56) | HTR1AMETLMNA | |
| SCHEMBL4432526 | 0.75 | CYP19A1 (0.51) | HTR1AADRA1DADRA1AADRA1BMET | |
| SCHEMBL7156011 | 0.75 | HTR1A (0.56) | HTR1AADRA1DADRA1AADRA1BMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0680967-B1 | Erythromycin derivatives, their process of preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (FR) | 1998-10-14 | — | — | EP | claimed |
| EP-0680967-B1 | Erythromycin derivatives, their process of preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (FR) | 1998-10-14 | — | — | EP | disclosed |
| EP-0680967-A1 | Erythromycin derivatives, their process of preparation and their use as medicaments | ROUSSEL-UCLAF (FR) | 1995-11-08 | — | — | EP | disclosed |