SCHEMBL8666792

SCHEMBL8666792

O=C(Nc1ncnc2c1ncn2[C@H]1CC(NC(c2ccccc2)(c2ccccc2)c2ccccc2)[C@@H](COC(=O)c2ccccc2)O1)c1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
P2RY12 Q9H244 8/20 0.44
LMNA P02545 1/20 0.42
P2RY2 P41231 1/20 0.42
P2RY1 P47900 1/20 0.42
P2RY6 Q15077 1/20 0.42
DNPH1 O43598 2/20 0.41
PRMT6 Q96LA8 1/20 0.40
TYMP P19971 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7516040 1.00 P2RY12 (0.44) P2RY12LMNAP2RY2P2RY1P2RY6
SCHEMBL6471947 0.90 ADORA1 (0.44)
SCHEMBL21063251 0.90 ADORA1 (0.44)
SCHEMBL29551585 0.90 ADORA1 (0.44)
SCHEMBL6471942 0.90 ADORA1 (0.44)
SCHEMBL19771221 0.89 P2RY12 (0.43) P2RY12P2RY2P2RY1P2RY6PRMT6
SCHEMBL19767623 0.89 P2RY12 (0.43) P2RY12P2RY2P2RY1P2RY6PRMT6
SCHEMBL17283109 0.89 P2RY12 (0.43) P2RY12P2RY2P2RY1P2RY6DNPH1
SCHEMBL19519464 0.89 P2RY12 (0.43) P2RY12P2RY2P2RY1P2RY6DNPH1
SCHEMBL7521379 0.88 P2RX3 (0.49) P2RY1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0882059-A1 SOLID PHASE SYNTHESIS OF OLIGONUCLEOTIDE N3-'P5'- PHOSPHORAMIDATES LYNX THERAPEUTICS, INC. (US) 1998-12-09 EP disclosed
WO-1997031009-A1 SOLID PHASE SYNTHESIS OF OLIGONUCLEOTIDE N3'→P5' PHOSPHORAMIDATES LYNX THERAPEUTICS, INC. (US) 1997-08-28 WO disclosed