Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | INSR | P06213 | 6/20 | 0.40 |
| ▸ | KDM4A | O75164 | 4/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL8917095 | 0.85 | MEN1 (0.58) | MEN1KMT2ANPC1ATMINSR | |
| Bromide SCHEMBL8562510 | 0.74 | MEN1 (0.47) | MEN1KMT2ANPC1ATMINSR | |
| Bromide SCHEMBL8813009 | 0.74 | MEN1 (0.47) | MEN1KMT2ANPC1ATMINSR | |
| Bromide SCHEMBL736011 | 0.74 | MEN1 (0.47) | MEN1KMT2ANPC1ATMINSR | |
| SCHEMBL29378819 | 0.73 | MEN1 (0.49) | MEN1KMT2ANPC1ATMINSR | |
| SCHEMBL12215003 | 0.73 | MEN1 (0.49) | MEN1KMT2ANPC1ATMINSR | |
| SCHEMBL14429919 | 0.73 | MEN1 (0.49) | MEN1KMT2ANPC1ATMINSR | |
| SCHEMBL8746783 | 0.73 | MEN1 (0.49) | MEN1KMT2ANPC1ATMINSR | |
| Iodide SCHEMBL8670273 | 0.72 | MEN1 (0.51) | MEN1KMT2ANPC1ATMINSR | |
| Bromide SCHEMBL9065129 | 0.70 | MEN1 (0.50) | MEN1KMT2ANPC1ATMINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5790627-A | Method and apparatus for observing a specimen using an X-ray microscope | RESEARCH DEVELOPMENT CORP. (JP) | 1998-08-04 | — | — | US | disclosed |