Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | INSR | P06213 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | RAD52 | P43351 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8813009 | 0.85 | MEN1 (0.47) | MEN1KMT2ANPC1ATMRAB9A | |
| Bromide SCHEMBL8562510 | 0.85 | MEN1 (0.47) | MEN1KMT2ANPC1ATMRAB9A | |
| Bromide SCHEMBL736011 | 0.85 | MEN1 (0.47) | MEN1KMT2ANPC1ATMRAB9A | |
| SCHEMBL12215003 | 0.83 | MEN1 (0.49) | MEN1KMT2ANPC1ATMRAB9A | |
| SCHEMBL14429919 | 0.83 | MEN1 (0.49) | MEN1KMT2ANPC1ATMRAB9A | |
| SCHEMBL29378819 | 0.83 | MEN1 (0.49) | MEN1KMT2ANPC1ATMRAB9A | |
| SCHEMBL8746783 | 0.83 | MEN1 (0.49) | MEN1KMT2ANPC1ATMRAB9A | |
| Iodide SCHEMBL8670276 | 0.83 | MEN1 (0.58) | MEN1KMT2ANPC1ATMRAB9A | |
| Iodide SCHEMBL8670273 | 0.82 | MEN1 (0.51) | MEN1KMT2ANPC1ATMRAB9A | |
| SCHEMBL11949196 | 0.78 | TERT (0.46) | MEN1KMT2ANPC1ATMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525398-B1 | Method of preparing specimen for classifying and counting leukocytes | TOA MEDICAL ELECTRONICS (JP) | 1996-06-12 | — | — | EP | disclosed |
| EP-0525397-A2 | Method of preparing specimen for classifying and counting leukocytes | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1993-02-03 | — | — | EP | disclosed |
| EP-0525398-A2 | Method of preparing specimen for classifying and counting leukocytes | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1993-02-03 | — | — | EP | disclosed |