SCHEMBL8668592

SCHEMBL8668592

N#Cc1cccc([CH]Cc2cccc(C#N)c2)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FBP1 P09467 3/20 0.45
GRIN2D O15399 2/20 0.44
GRIN3B O60391 2/20 0.44
GRIN1 Q05586 2/20 0.44
GRIN2A Q12879 2/20 0.44
GRIN2B Q13224 2/20 0.44
GRIN2C Q14957 2/20 0.44
GRIN3A Q8TCU5 2/20 0.44
GLA P06280 1/20 0.44
CYP19A1 P11511 1/20 0.42
CYP11B1 P15538 1/20 0.42
CYP11B2 P19099 1/20 0.42
HRH3 Q9Y5N1 1/20 0.42
PDCD1 Q15116 1/20 0.40
CD274 Q9NZQ7 1/20 0.40
P4HB P07237 3/20 0.40
MRGPRX4 Q96LA9 1/20 0.40
MEP1A Q16819 1/20 0.40
MEP1B Q16820 1/20 0.40
HDAC4 P56524 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4857111 0.83 MRGPRX4 (0.49) GLACYP19A1CYP11B1CYP11B2HRH3
SCHEMBL30646949 0.79 GLA (0.51) FBP1GLACYP19A1CYP11B1CYP11B2
SCHEMBL16619152 0.79 PDCD1 (0.50) FBP1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL253203 0.79 GLA (0.51) FBP1GLACYP19A1CYP11B1CYP11B2
SCHEMBL19437290 0.79 GLA (0.42) GLACYP19A1CYP11B1CYP11B2HRH3
SCHEMBL2162055 0.78 GLA (0.46) GLACYP19A1CYP11B1CYP11B2HRH3
SCHEMBL28728197 0.78 GLA (0.46) GLACYP19A1CYP11B1CYP11B2HRH3
SCHEMBL27336648 0.78 GRIN2D (0.50) FBP1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL28879916 0.78 GLA (0.46) GLACYP19A1CYP11B1CYP11B2HRH3
SCHEMBL4137313 0.77 ALDH1A1 (0.42) FBP1GRIN2DGRIN3BGRIN1GRIN2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5811422-A USEFUL FOR TREATING VIRAL INFECTIONS THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) 1998-09-22 US disclosed
US-5610294-A VIRAL TREATMENT THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1997-03-11 US disclosed