Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 3/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | LSS | P48449 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.34 |
| ▸ | AGXT | P21549 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5871483 | 0.81 | TAAR1 (0.45) | IDO1LOXL2TAAR1 | |
| Hydrochloric Acid SCHEMBL5812081 | 0.81 | IDO1 (0.34) | IDO1LOXL2TAAR1AGXTRAB9A | |
| SCHEMBL596253 | 0.79 | HIF1A (0.39) | CHRNB2CHRNA4LSSCHRNA7ALDH1A1 | |
| SCHEMBL11846749 | 0.77 | HIF1A (0.41) | CHRNB2CHRNA4IDO1LOXL2CHRNA7 | |
| SCHEMBL270821 | 0.76 | SIGMAR1 (0.41) | CHRNB2CHRNA4LSSCHRNA7ALDH1A1 | |
| SCHEMBL1983107 | 0.73 | CHRNA7 (0.61) | CHRNB2CHRNA4IDO1LOXL2TAAR1 | |
| SCHEMBL1831948 | 0.72 | HIF1A (0.41) | CHRNB2CHRNA4IDO1LOXL2ALDH1A1 | |
| SCHEMBL5030489 | 0.72 | PLA2G1B (0.33) | TAAR1ALDH1A1RAB9A | |
| SCHEMBL12493084 | 0.67 | MAOB (0.43) | CHRNA7 | |
| SCHEMBL15804405 | 0.67 | HPGD (0.35) | CHRNB2CHRNA4IDO1LOXL2TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880512-A1 | NOVEL AROMATIC PIPERAZINES DERIVED FROM SUBSTITUTED CYCLOAZANES, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS DRUGS | PIERRE FABRE MEDICAMENT (FR) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028141-A1 | NOVEL AROMATIC PIPERAZINES DERIVED FROM SUBSTITUTED CYCLOAZANES, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS DRUGS | PIERRE FABRE MEDICAMENT (FR) | 1997-08-07 | — | — | WO | disclosed |