Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 18/20 | 0.46 |
| ▸ | PPARA | Q07869 | 16/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8500896 | 0.75 | KDM4E (0.46) | KDM4EPPARGPPARACYP2C9CYP3A4 | |
| Darglitazone SCHEMBL37497 | 0.74 | PPARG (0.48) | KDM4EPPARGPPARACYP2C9CYP3A4 | |
| Darglitazone SCHEMBL9436449 | 0.74 | PPARG (0.48) | KDM4EPPARGPPARACYP2C9CYP3A4 | |
| Darglitazone SCHEMBL20125582 | 0.74 | PPARG (0.48) | KDM4EPPARGPPARACYP2C9CYP3A4 | |
| Darglitazone SCHEMBL243882 | 0.73 | PPARG (0.44) | KDM4EPPARGPPARACYP2C9CYP3A4 | |
| Darglitazone SCHEMBL674635 | 0.73 | PPARG (0.48) | KDM4EPPARGPPARACYP2C9CYP3A4 | |
| SCHEMBL5819389 | 0.73 | PPARG (0.57) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| SCHEMBL5798422 | 0.73 | PPARG (0.55) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| SCHEMBL6037063 | 0.73 | MAPT (0.52) | KDM4EPPARGCYP2C9CYP3A4 | |
| SCHEMBL4034559 | 0.72 | KDM4E (0.73) | KDM4EPPARGPPARAFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753681-A | INSULIN SENSITIZERS | SANKYO COMPANY, LIMITED (JP) | 1998-05-19 | — | — | US | claimed |
| US-5753681-A | INSULIN SENSITIZERS | SANKYO COMPANY, LIMITED (JP) | 1998-05-19 | — | — | US | disclosed |