Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 8/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.41 |
| ▸ | KYAT3 | Q6YP21 | 1/20 | 0.41 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | CCL2 | P13500 | 7/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8532730 | 0.87 | BRD4 (0.52) | BRD4ALDH1A1MAPTKYAT1KYAT3 | |
| SCHEMBL19657303 | 0.77 | HSD17B10 (0.38) | BRD4AADATLMNACCL2MGLL | |
| SCHEMBL19657298 | 0.77 | HSD17B10 (0.38) | BRD4AADATLMNACCL2MGLL | |
| SCHEMBL30984391 | 0.77 | HSD17B10 (0.38) | BRD4AADATLMNACCL2MGLL | |
| SCHEMBL10695734 | 0.76 | TNKS2 (0.48) | BRD4ALDH1A1MAPT | |
| SCHEMBL26688764 | 0.76 | GRIA1 (0.37) | BRD4ALDH1A1SRD5A1 | |
| SCHEMBL19644092 | 0.76 | MEN1 (0.47) | BRD4ALDH1A1LMNACCL2MGLL | |
| SCHEMBL29704482 | 0.76 | MEN1 (0.47) | BRD4ALDH1A1LMNACCL2MGLL | |
| SCHEMBL8667942 | 0.76 | EGFR (0.36) | BRD4MAPTCCL2 | |
| SCHEMBL25295086 | 0.75 | CYP2A6 (0.38) | BRD4ALDH1A1MAPTCCL2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260452-A | 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-11-09 | — | — | US | claimed |
| US-5726323-A | COMPOUNDS USEFUL FOR ALLEVIATING MEMORY DYSFUNCTIONS | HOECHST MARION ROUSSEL, INC. | 1998-03-10 | — | — | US | disclosed |
| US-5591864-A | CHEMICAL INTERMEDIATES FOR COMPOUNDS WHICH ALLEVIATE MEMORY DYSFUNCITONS | HOECHST MARION ROUSSEL, INC. (US) | 1997-01-07 | — | — | US | disclosed |
| EP-0484573-B1 | 4- and 6-Carbamates related to physostigmine, a process and intermediates for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-03-13 | — | — | EP | disclosed |
| US-5260452-A | 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-11-09 | — | — | US | disclosed |
| EP-0484573-A1 | 4- and 6-Carbamates related to physostigmine, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-05-13 | — | — | EP | disclosed |
| US-5081117-A | Treatment of memory dysfunctions such as in Alzheimer's disease | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-01-14 | — | — | US | disclosed |