Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10696186 | 0.84 | KMT2A (0.43) | TNKS2KDM4EALDH1A1MAPTGAA | |
| SCHEMBL10694150 | 0.84 | KDM4E (0.43) | TNKS2KDM4EALDH1A1MAPTGAA | |
| SCHEMBL10699606 | 0.83 | TNKS2 (0.43) | TNKS2KDM4EALDH1A1MAPTGAA | |
| SCHEMBL10700358 | 0.83 | TNKS2 (0.43) | TNKS2KDM4EALDH1A1MAPTGAA | |
| SCHEMBL8532730 | 0.76 | BRD4 (0.52) | ALDH1A1MAPTGAABRD4SMN1; SMN2 | |
| SCHEMBL8669199 | 0.76 | BRD4 (0.56) | ALDH1A1MAPTBRD4 | |
| SCHEMBL10695479 | 0.75 | KDM4E (0.45) | KDM4EALDH1A1MAPTGAAKMT2A | |
| SCHEMBL10695278 | 0.74 | TNKS2 (0.48) | TNKS2KDM4EALDH1A1MAPTGAA | |
| SCHEMBL10695097 | 0.72 | PARP1 (0.40) | KDM4EALDH1A1MAPTGAAKMT2A | |
| SCHEMBL10698630 | 0.72 | KMT2A (0.37) | KDM4EALDH1A1MAPTGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |