Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.40 |
| ▸ | TYR | P14679 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326980 | 0.88 | NPC1 (0.57) | NPC1RAB9AALDH1A1MEN1LMNA | |
| SCHEMBL5129173 | 0.86 | ALDH1A1 (0.44) | NPC1RAB9AALDH1A1MEN1LMNA | |
| SCHEMBL13823608 | 0.84 | CYP2A6 (0.46) | NPC1RAB9AALDH1A1MEN1LMNA | |
| SCHEMBL5118727 | 0.81 | ALDH1A1 (0.50) | NPC1RAB9AALDH1A1MEN1LMNA | |
| SCHEMBL287047 | 0.80 | ALDH1A1 (0.41) | NPC1RAB9AALDH1A1MEN1LMNA | |
| SCHEMBL1613763 | 0.79 | ALDH1A1 (0.68) | NPC1RAB9AALDH1A1MEN1LMNA | |
| SCHEMBL1638724 | 0.79 | ALDH1A1 (0.72) | NPC1RAB9AALDH1A1MEN1LMNA | |
| SCHEMBL30567324 | 0.79 | ALDH1A1 (0.68) | NPC1RAB9AALDH1A1MEN1LMNA | |
| SCHEMBL4877265 | 0.78 | ALDH1A1 (0.70) | NPC1RAB9AALDH1A1MEN1LMNA | |
| SCHEMBL24191934 | 0.77 | CYP2A6 (0.47) | NPC1RAB9AALDH1A1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5721234-A | TREATING CONVULSIONS, ANXIETY, CEREBRAL HYPOXIA/ISCHEMIA, PARKINSON*S DISEASE | WARNER-LAMBERT COMPANY (US) | 1998-02-24 | — | — | US | disclosed |
| WO-1998005651-A1 | NOVEL GLUTAMATE RECEPTOR ANTAGONISTS: FUSED CYCLOALKYL QUINOXALINEDIONES | WARNER-LAMBERT COMPANY (US) | 1998-02-12 | — | — | WO | disclosed |
| WO-1996017832-A1 | NOVEL GLUTAMATE RECEPTOR ANTAGONISTS: FUSED CYCLOALKYLQUINOXALINEDIONES | WARNER-LAMBERT COMPANY (US) | 1996-06-13 | — | — | WO | disclosed |
| US-4510157-A | 6,7,8,9-Tetrahydro-1H-benz(g)indol-8-amine derivatives | AYERST, MCKENNA & HARRISON, INC. (CA) | 1985-04-09 | — | — | US | disclosed |