Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.47 |
| ▸ | APP | P05067 | 4/20 | 0.46 |
| ▸ | REN | P00797 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7270247 | 0.86 | ATM (0.62) | KLK5ATMPSEN1PSEN2APH1B | |
| SCHEMBL7299571 | 0.86 | ATM (0.62) | KLK5ATMPSEN1PSEN2APH1B | |
| SCHEMBL7305946 | 0.86 | ATM (0.62) | KLK5ATMPSEN1PSEN2APH1B | |
| SCHEMBL7301095 | 0.86 | ATM (0.62) | KLK5ATMPSEN1PSEN2APH1B | |
| SCHEMBL3801376 | 0.86 | CYP3A4 (0.50) | KLK5CASP3 | |
| SCHEMBL16283136 | 0.84 | KLK5 (0.59) | KLK5ATMPSEN1PSEN2APH1B | |
| SCHEMBL15159955 | 0.84 | KLK5 (0.59) | KLK5ATMPSEN1PSEN2APH1B | |
| SCHEMBL3099765 | 0.84 | CA2 (0.41) | KLK5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8889416 | 0.82 | KMT2A (0.47) | CASP3 | |
| SCHEMBL8670056 | 0.82 | KMT2A (0.47) | CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5763464-A | TREATING HUMAN IMMUNODEFICIENCY VIRUS INFECTIONS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1998-06-09 | — | — | US | disclosed |
| WO-1997019061-A1 | RETROVIRAL AGENTS CONTAINING ANTHRANILAMIDE, SUBSTITUTED BENZAMIDE AND OTHER SUBUNITS, AND METHODS OF USING SAME | THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1997-05-29 | — | — | WO | disclosed |