Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8670002 | 1.00 | PLA2G10 (0.30) | PLA2G10 | |
| Fumaric Acid SCHEMBL6969269 | 0.80 | KDM4E (0.32) | — | |
| Fumaric Acid SCHEMBL6969275 | 0.80 | KDM4E (0.32) | — | |
| Fumaric Acid SCHEMBL6971276 | 0.78 | MAPT (0.43) | — | |
| Fumaric Acid SCHEMBL6971267 | 0.78 | MAPT (0.43) | — | |
| Fumaric Acid SCHEMBL6972355 | 0.77 | CYP1A2 (0.31) | — | |
| Fumaric Acid SCHEMBL6972364 | 0.77 | CYP1A2 (0.31) | — | |
| Fumaric Acid SCHEMBL6972062 | 0.76 | MAPT (0.35) | — | |
| Fumaric Acid SCHEMBL6972073 | 0.76 | MAPT (0.35) | — | |
| Fumaric Acid SCHEMBL6960373 | 0.74 | MAPT (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750720-A | ALPHA-ADRENORECEPTORS AND CENTRAL NERVOUS SYSTEMS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1998-05-12 | — | — | US | disclosed |