Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 17/20 | 0.82 |
| ▸ | ADRA1A | P35348 | 17/20 | 0.82 |
| ▸ | ADRA1B | P35368 | 17/20 | 0.82 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HTR7 | P34969 | 2/20 | 0.51 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8670190 | 0.90 | ADRA1D (0.82) | ADRA1DADRA1AADRA1BHTR2AHTR7 | |
| SCHEMBL8670256 | 0.90 | ADRA1D (1.00) | ADRA1DADRA1AADRA1BHTR2AHTR7 | |
| SCHEMBL8670876 | 0.90 | ADRA1D (0.82) | ADRA1DADRA1AADRA1BHTR2AHTR7 | |
| SCHEMBL8669616 | 0.90 | ADRA1D (0.66) | ADRA1DADRA1AADRA1BHTR2AHTR7 | |
| SCHEMBL8672465 | 0.88 | ADRA1D (0.67) | ADRA1DADRA1AADRA1BHTR2AHTR7 | |
| SCHEMBL8672459 | 0.88 | ADRA1D (0.67) | ADRA1DADRA1AADRA1BHTR2AHTR7 | |
| SCHEMBL8671103 | 0.87 | ADRA1D (0.66) | ADRA1DADRA1AADRA1BHTR2AHTR7 | |
| SCHEMBL8669077 | 0.86 | ADRA1D (0.83) | ADRA1DADRA1AADRA1BHTR2AHTR7 | |
| SCHEMBL8667687 | 0.86 | ADRA1D (0.70) | ADRA1DADRA1AADRA1BHTR2AHTR7 | |
| SCHEMBL8674153 | 0.82 | ADRA1D (0.82) | ADRA1DADRA1AADRA1BHTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5760054-A | BENIGN PROSTATIC HYPERTROPHY | MERCK & CO., INC. (US) | 1998-06-02 | — | — | US | disclosed |
| EP-0755392-A4 | ALPHA1C ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1997-05-02 | — | — | EP | disclosed |
| EP-0755392-A1 | ALPHA1C ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO. INC. (US) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028397-A1 | ALPHA1C ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1995-10-26 | — | — | WO | disclosed |