Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30536712 | 1.00 | CYP3A4 (0.52) | CYP3A4TRPA1ALDH1A1MAPTGAA | |
| SCHEMBL7787561 | 0.81 | KMT2A (0.44) | CYP3A4TRPA1ALDH1A1MAPTGAA | |
| SCHEMBL7787560 | 0.81 | KMT2A (0.44) | CYP3A4TRPA1ALDH1A1MAPTGAA | |
| SCHEMBL10514797 | 0.79 | MAPT (0.40) | ALDH1A1MAPTGAATP53TSHR | |
| SCHEMBL5725150 | 0.79 | ALDH1A1 (0.51) | CYP3A4ALDH1A1MAPTGAATP53 | |
| SCHEMBL14180515 | 0.77 | TDP1 (0.48) | CYP3A4ALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL29395383 | 0.77 | CYP3A4 (0.64) | CYP3A4TRPA1ALDH1A1MAPTGAA | |
| SCHEMBL15431 | 0.77 | CYP3A4 (0.64) | CYP3A4TRPA1ALDH1A1MAPTGAA | |
| SCHEMBL27558099 | 0.76 | CYP3A4 (0.44) | CYP3A4TRPA1ALDH1A1MAPTKDM4E | |
| SCHEMBL30882155 | 0.76 | MAPT (0.45) | ALDH1A1MAPTGAATP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107176925-A | A kind of synthetic method of the cyclohexadione compounds of polysubstituted imidazoline 2,4 | 湖北科技学院 | 2017-09-19 | — | — | CN | claimed |
| EP-3298194-A2 | METHODS FOR TREATING PAPERBOARDS AND PAPER MEDIA, AND ASSOCIATED PAPERBOARDS AND PAPER MEDIA | BASF SE (DE) | 2018-03-28 | — | — | EP | disclosed |
| CN-107176925-A | A kind of synthetic method of the cyclohexadione compounds of polysubstituted imidazoline 2,4 | 湖北科技学院 | 2017-09-19 | — | — | CN | disclosed |
| CN-102917883-B | Method for manufacturing Heat-sensitive recording material | MITSUBISHI PAPER MILLS LTD | 2015-01-14 | — | — | CN | disclosed |
| US-8785424-B2 | ngCycloartanone derivatives with anticancer activity | PIERRE FABRE MEDICAMENT (FR) | 2014-07-22 | — | — | US | disclosed |
| CN-102917883-A | Heat-sensitive recording material and method for manufacturing the same | MITSUBISHI PAPER MILLS LTD | 2013-02-06 | — | — | CN | disclosed |
| US-20120077777-A1 | NGCYCLOARTANONE DERIVATIVES WITH ANTICANCER ACTIVITY | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2012-03-29 | — | — | US | disclosed |
| WO-2011019612-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOAL AGENTS | ANACOR PHARMACEUTICALS, INC. (US) | 2011-02-17 | — | — | WO | disclosed |
| EP-1901745-A2 | SYNERGISTIC MODULATION OF FLT3 KINASE USING AMINOPYRIMIDINES KINASE MODULATORS AND A FARNESYL TRANSFERASE INHIBITOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-26 | — | — | EP | disclosed |
| EP-1898917-A1 | AMINOPYRIMIDINES AS KINASE MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2008-03-19 | — | — | EP | disclosed |
| EP-0297996-A2 | Lubricating oil compositions and fuel compositions containing substantially straight chain alkylphenyl poly(oxypropylene) aminocarbamates | CHEVRON RESEARCH AND TECHNOLOGY COMPANY (US) | 1989-01-04 | — | — | EP | disclosed |
| US-4329240-A | POLYOXYALKYLENE AMINOCARBAMATES | CHEVRON RESEARCH COMPANY (US) | 1982-05-11 | — | — | US | disclosed |
| US-4294714-A | Carboxylic acid salt containing deposit control additives and fuel and lube oil compositions containing them | CHEVRON RESEARCH COMPANY (US) | 1981-10-13 | — | — | US | disclosed |
| US-4289634-A | SALT OF OXYACID ESTER OF PHOSPHORUS AND A HYDROCARBYL POLYOXYALKYLENE AMINOALKYL CARBAMATE | CHEVRON RESEARCH COMPANY (US) | 1981-09-15 | — | — | US | disclosed |
| US-4288612-A | HYDROCARBYL-POLY(OXYALKYLENE) AMINOCARBAMATE FUEL ADDITIVES | CHEVRON RESEARCH COMPANY (US) | 1981-09-08 | — | — | US | disclosed |
| US-4274837-A | HYDROCARBLY-POLYOXYALKYLENE-AMINOCARBAMATES | CHEVRON RESEARCH COMPANY (US) | 1981-06-23 | — | — | US | disclosed |
| US-4233168-A | POLYOXYALKYLENE AMINOCARBAMATES | CHEVRON RESEARCH COMPANY (US) | 1980-11-11 | — | — | US | disclosed |
| US-4197409-A | ANTIDEPOSITE FUEL ADDITIVES OR OIL ADDITIVES | CHEVRON RESEARCH COMPANY (US) | 1980-04-08 | — | — | US | disclosed |
| US-4191537-A | ANTIDEPOSIT AGENTS | CHEVRON RESEARCH COMPANY (US) | 1980-03-04 | — | — | US | disclosed |
| US-3937824-A | COMPOSITIONS AND METHODS OF KILLING INSECTS AND ACARIDS USING ALKOXYIMINO CARBAMOYLOXY PHOSPHORUS COMPOUNDS | VELSICOL CHEMICAL CORPORATION (US) | 1976-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077777-A1 | NGCYCLOARTANONE DERIVATIVES WITH ANTICANCER ACTIVITY | PKD1, NME1, NGLY1 | CYP3A4 1876/4885TRPA1 4002/4885ALDH1A1 787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.