SCHEMBL8672840

CC=C([Si](c1ccccc1)(c1ccccc1)c1ccccc1)[PH](O)(O[C@H]1C[C@H](n2ccc(NC(=O)c3ccccc3)nc2=O)O[C@@H]1COC(c1ccccc1)(c1ccc(OC)cc1)c1ccc(OC)cc1)N(C(C)C)C(C)C

nearest known ligand 0.47

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	POLB	P06746	1/20	0.47

▸	ABL1	P00519	1/20	0.39

▸	RIN1	Q13671	1/20	0.39

▸	P2RY6	Q15077	2/20	0.36

▸	P2RY14	Q15391	2/20	0.36

▸	NT5E	P21589	2/20	0.36

▸	TYMP	P19971	2/20	0.34

▸	ADORA3	P0DMS8	1/20	0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL5925228	0.85	POLB (0.48)	POLBABL1RIN1P2RY6P2RY14
SCHEMBL8669460	0.84	TYMP (0.39)	TYMP
SCHEMBL7037018	0.84	POLB (0.47)	POLBABL1RIN1P2RY6P2RY14
SCHEMBL6932396	0.83	POLB (0.59)	POLBABL1RIN1P2RY6P2RY14
SCHEMBL17992980	0.82	POLB (0.59)	POLBABL1RIN1P2RY6P2RY14
SCHEMBL8027766	0.81	RNASE1 (0.41)	TYMP
SCHEMBL30165345	0.81	POLB (0.54)	POLBABL1RIN1P2RY6P2RY14
SCHEMBL7999768	0.81	POLB (0.47)	POLBABL1RIN1P2RY6P2RY14
SCHEMBL23157266	0.80	POLB (0.56)	POLBABL1RIN1P2RY6P2RY14
SCHEMBL23056641	0.80	POLB (0.56)	POLBABL1RIN1P2RY6P2RY14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-5705621-A	Oligomeric phosphite, phosphodiester, Phosphorothioate and phosphorodithioate compounds and intermediates for preparing same	ISIS PHARMACEUTICALS, INC. (US)	1998-01-06	—	—	US	disclosed