SCHEMBL867291

SCHEMBL867291

O=C1C=C(Br)CC1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL678750 0.82
SCHEMBL9368368 0.65
SCHEMBL9613579 0.62
SCHEMBL124557 0.62
SCHEMBL868082 0.62
SCHEMBL8710484 0.62
SCHEMBL13508674 0.62
SCHEMBL3974043 0.62
SCHEMBL11113778 0.61
SCHEMBL15456369 0.61 POLB (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 162 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4027995-B1 HPK1 ANTAGONISTS AND USES THEREOF NIMBUS SATURN INC (US) 2026-05-27 EP disclosed
CN-121779218-A Preparation method of 3-bromo-2-cyclopentene-1-one 宿迁晨阳医药科技有限公司 2026-04-03 CN disclosed
US-20260078117-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS INC (US) 2026-03-19 US disclosed
US-20260008775-A1 AZOLE MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION CONVELO THERAPEUTICS, INC. 2026-01-08 US disclosed
EP-4594309-A1 AZOLE MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION Genentech Inc. (US) 2025-08-06 EP disclosed
US-12304907-B2 Compounds and methods of use TANGO THERAPEUTICS, INC. (US) 2025-05-20 US disclosed
CN-120019049-A Azole modulators of cholesterol biosynthesis and their use for promoting remyelination 基因泰克公司 2025-05-16 CN disclosed
US-12264169-B2 Heteroaryl inhibitors of PDE4 Tetra Discovery Partners (US) 2025-04-01 US disclosed
US-12264154-B2 Compounds and methods of use TANGO THERAPEUTICS, INC. (US) 2025-04-01 US disclosed
US-12215105-B2 HPK1 antagonists and uses thereof Nimbus Saturn, Inc. (US) 2025-02-04 US disclosed
US-20120122941-A1 CYCLOALKYLAMINE DERIVATIVES MARUMOTO SHINJI (JP) 2012-05-17 US disclosed
US-20120077814-A1 SULFONAMIDE, SULFAMATE, AND SULFAMOTHIOATE DERIVATIVES WANG ZHONG (US) 2012-03-29 US disclosed
US-20120077814-A1 SULFONAMIDE, SULFAMATE, AND SULFAMOTHIOATE DERIVATIVES WANG ZHONG (US) 2012-03-29 US disclosed
US-20120077814-A1 SULFONAMIDE, SULFAMATE, AND SULFAMOTHIOATE DERIVATIVES WANG ZHONG (US) 2012-03-29 US disclosed
EP-2341044-A1 CYCLOALKYLAMINE DERIVATIVE Daiichi Sankyo Company, Limited (JP) 2011-07-06 EP disclosed
US-7348328-B2 MCH antagonists for the treatment of obesity SCHERING CORPORATION (US) 2008-03-25 US disclosed
US-6495370-B1 A METHOD FOR DETECTING A GLUTATHIONE-S-TRANSFERASE ISOENZYME IN A BIOLOGICAL SPECIMEN COMPRISING THE MEASUREMENT OF GLUTATHIONE-S-TRANSFERASE ENZYMATIC ACTIVITY IN THE PRESENCE AND ABSENCE AN AMOUNT OF A COMPOUND OF THE FORMULA HALO THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2002-12-17 US disclosed
US-6103665-A Inhibition of glutathione transferase by haloenol lactones THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2000-08-15 US disclosed
US-5767147-A MEDICAL DIAGNOSIS, TREATMENT OF DRUG RESISTANCE IN CANCER THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1998-06-16 US disclosed
WO-1996032936-A1 INHIBITION OF GLUTATHIONE TRANSFERASE BY HALOENOL LACTONES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1996-10-24 WO disclosed