SCHEMBL8673149

SCHEMBL8673149

COc1nc(NC(=O)Oc2ccccc2)nc(OC)n1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.54
GAA P10253 3/20 0.54
HTT P42858 3/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
MAPT P10636 3/20 0.50
MEN1 O00255 3/20 0.48
KMT2A Q03164 3/20 0.48
POLB P06746 1/20 0.48
F2 P00734 1/20 0.47
F12 P00748 1/20 0.47
KDM4E B2RXH2 2/20 0.47
THRB P10828 1/20 0.47
GFER P55789 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
LMNA P02545 1/20 0.46
TP53 P04637 1/20 0.46
CYP1A2 P05177 1/20 0.46
RAD51 Q06609 1/20 0.45
GLA P06280 1/20 0.45
HPGD P15428 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2893620 0.91 ALDH1A1 (0.49) ALDH1A1GAAHTTSMN1; SMN2MAPT
SCHEMBL9368620 0.87 ALDH1A1 (0.45) ALDH1A1GAAHTTSMN1; SMN2MAPT
SCHEMBL9620601 0.85 ALDH1A1 (0.49) ALDH1A1GAAHTTSMN1; SMN2MAPT
SCHEMBL7244914 0.85 ALDH1A1 (0.56) ALDH1A1GAAHTTSMN1; SMN2MAPT
SCHEMBL27456552 0.84 ALDH1A1 (0.54) ALDH1A1MAPTMEN1KMT2APOLB
SCHEMBL1576702 0.83 MAPT (0.59) ALDH1A1GAAHTTSMN1; SMN2MAPT
SCHEMBL15890196 0.81 NPC1 (0.59) ALDH1A1GAAHTTSMN1; SMN2MAPT
SCHEMBL27545158 0.81 ALDH1A1 (0.53) ALDH1A1GAAHTTSMN1; SMN2MAPT
SCHEMBL897079 0.80 ALDH1A1 (0.49) ALDH1A1GAAHTTSMN1; SMN2MAPT
SCHEMBL9661273 0.80 POLB (0.53) ALDH1A1GAAHTTSMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-60139691-A None JP disclosed
JP-60028977-A None JP disclosed
CN-114456120-B Bissulfonylamino substituted sulfonylurea compound, and preparation method and application thereof 郑州手性药物研究院有限公司 2024-06-18 CN disclosed
CN-1208037-A Intermediate for synthesizing fluopropyl thiazoline derivative NISSAN CHEMICAL IND LTD (JP) 1999-02-17 CN disclosed
US-5763365-A CONTROLLING WEEDS IN SUGAR BEET FIELDS NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1998-06-09 US disclosed
CN-1037349-C Fluoropropyl thiazoline derivative and herbicide NISSAN CHEMICAL IND LTD (JP) 1998-02-11 CN disclosed
CN-1138331-A Fluoropropyl thiazoline derivative and herbicide NISSAN CHEMICAL IND LTD (JP) 1996-12-18 CN disclosed
EP-0739893-A1 FLUOROPROPYLTHIAZOLINE DERIVATIVE AND HERBICIDE NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1996-10-30 EP disclosed
CN-1108656-A N-azinyl-N'-(HET)arylsulphonyl-ureas BAYER AG (DE) 1995-09-20 CN disclosed
CN-1011309-B PROCESS FOR PREPARING SUBSTITUTED THIOPHENESULFONAMIDE AND SALTS THEREOF USED AS HERBICIDES ISHIHARA SANGYO KAISHA (JP) 1991-01-23 CN disclosed
US-4741765-A Herbicidal sulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1988-05-03 US disclosed
US-4678499-A PRE- AND POSTEMERGENCE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-07-07 US disclosed
CN-85101667-A The aminosulfonylthiophene compound that replaces and the preparation method of its esters and as the purposes of weedicide 1987-01-17 CN disclosed
EP-0203679-A2 Herbicidal sulfonamides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1986-12-03 EP disclosed
US-4620868-A N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3[halo-substituted ethenyl (or propenyl)]-2-thiophenesulfonamides useful as herbicides ISHIHARA SANGYO KAISHA, LTD. (JP) 1986-11-04 US disclosed
JP-S60139691-A SUBSTITUTED THIOPHENESULFONAMIDE BASED COMPOUND AND HERBICIDE CONTAINING THE SAME ISHIHARA SANGYO KAISHA LTD 1985-07-24 JP disclosed
JP-S6028977-A SUBSTITUTED BENZENESULFONAMIDE COMPOUND AND HERBICIDE CONTAINING THE SAME ISHIHARA SANGYO KAISHA LTD 1985-02-14 JP disclosed