⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2273019 | 0.78 | — | — | |
| SCHEMBL1446017 | 0.78 | — | — | |
| SCHEMBL207433 | 0.76 | — | — | |
| SCHEMBL14029230 | 0.76 | — | — | |
| SCHEMBL20221160 | 0.76 | — | — | |
| SCHEMBL19965813 | 0.76 | — | — | |
| SCHEMBL12049258 | 0.74 | — | — | |
| SCHEMBL27504265 | 0.74 | PHF8 (0.30) | — | |
| SCHEMBL4195366 | 0.74 | PHF8 (0.33) | — | |
| SCHEMBL25762055 | 0.72 | CHRNB2 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |
| US-20060100431-A1 | Biologically active compounds | AMURA THERAPEUTICS LIMITED (GB) | 2006-05-11 | — | — | US | claimed |
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | claimed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | claimed |
| US-11602527-B2 | Methods of use of cyclopamine analogs | INFINITY PHARMACEUTICALS, INC. (US) | 2023-03-14 | — | — | US | disclosed |
| US-20210275508-A1 | METHODS OF USE OF CYCLOPAMINE ANALOGS | INFINITY PHARMACEUTICALS, INC. | 2021-09-09 | — | — | US | disclosed |
| US-11007181-B2 | Cyclopamine analogs | INFINITY PHARMACEUTICALS, INC. (US) | 2021-05-18 | — | — | US | disclosed |
| US-10821102-B2 | Methods of use of cyclopamine analogs | INFINITY PHARMACEUTICALS, INC. (US) | 2020-11-03 | — | — | US | disclosed |
| US-20200121658-A1 | CYCLOPAMINE ANALOGS | ROYALTY SECURITY, LLC | 2020-04-23 | — | — | US | disclosed |
| US-10406139-B2 | Cyclopamine analogs | INFINITY PHARMACEUTICALS, INC. (US) | 2019-09-10 | — | — | US | disclosed |
| EP-2767577-B1 | Additive compositions with a friction modifier and a dispersant | AFTON CHEMICAL CORP (US) | 2019-08-28 | — | — | EP | disclosed |
| US-10314827-B2 | Methods of use of cyclopamine analogs | INFINITY PHARMACEUTICALS, INC. (US) | 2019-06-11 | — | — | US | disclosed |
| US-4256746-A | ANTITUMOR AGENTS; MICROBIOCIDES; MITOSIS | TAKEDA CHEMICAL INDUSTRIES (JP) | 1981-03-17 | — | — | US | disclosed |
| EP-0014402-A1 | Novel 20-0-acylmaytansinoids, process for their preparation and pharmaceutical compositions containing them | Takeda Chemical Industries, Ltd. (JP) | 1980-08-20 | — | — | EP | disclosed |
| EP-0011277-A1 | Dechloromaytansinoids, their production and use and pharmaceutical compositions containing them | Takeda Chemical Industries, Ltd. (JP) | 1980-05-28 | — | — | EP | disclosed |
| EP-0011276-A1 | Maytansinoids, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1980-05-28 | — | — | EP | disclosed |
| EP-0004466-A1 | Demethyl maytansinoids and methods for producing them | Takeda Chemical Industries, Ltd. (JP) | 1979-10-03 | — | — | EP | disclosed |
| US-4044123-A | ANTIBIOTICS | SCHERING CORPORATION (US) | 1977-08-23 | — | — | US | disclosed |
| US-4002608-A | ANTIBACTERIALS | SCHERING CORPORATION (US) | 1977-01-11 | — | — | US | disclosed |
| US-4002742-A | 1-N-alkyl-4,6-di-(aminoglycosyl)-1,3-diaminocyclitols, methods for their manufacture, methods for their use as antibacterial agents, and compositions useful therefor | SCHERING CORPORATION (US) | 1977-01-11 | — | — | US | disclosed |