SCHEMBL867346

SCHEMBL867346

CC(NS(=O)(=O)c1cccc2c(N(C)C)cccc12)C(=O)O

nearest known ligand 0.55

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
F2 P00734 2/20 0.55
PRSS1 P07477 2/20 0.55
PRSS2 P07478 2/20 0.55
PRSS3 P35030 2/20 0.55
EDNRA P25101 7/20 0.53
CA2 P00918 1/20 0.52
KDM4E B2RXH2 1/20 0.50
NSD2 O96028 1/20 0.50
TSHR P16473 1/20 0.50
HSD17B10 Q99714 1/20 0.50
HDAC4 P56524 1/20 0.50
HDAC10 Q969S8 1/20 0.50
HDAC6 Q9UBN7 1/20 0.50
HDAC5 Q9UQL6 1/20 0.50
HDAC1 Q13547 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL867347 1.00 F2 (0.55) F2PRSS1PRSS2PRSS3EDNRA
SCHEMBL29683331 1.00 F2 (0.55) F2PRSS1PRSS2PRSS3EDNRA
Cyclohexylamine SCHEMBL30763312 0.88 F2 (0.54) F2PRSS1PRSS2PRSS3CA2
Cyclohexylamine SCHEMBL15918671 0.88 F2 (0.54) F2PRSS1PRSS2PRSS3CA2
Cyclohexylamine SCHEMBL29197249 0.88 F2 (0.54) F2PRSS1PRSS2PRSS3CA2
SCHEMBL10966272 0.87 F2 (0.53) F2PRSS1PRSS2PRSS3EDNRA
SCHEMBL10965358 0.87 F2 (0.53) F2PRSS1PRSS2PRSS3EDNRA
SCHEMBL10964796 0.86 F2 (0.52) F2PRSS1PRSS2PRSS3EDNRA
SCHEMBL4128595 0.86 F2 (0.52) F2PRSS1PRSS2PRSS3EDNRA
SCHEMBL28739997 0.86 F2 (0.52) F2PRSS1PRSS2PRSS3EDNRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 171 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114195878-A Ubiquitin mutant and preparation method and application thereof 中国人民解放军军事科学院军事医学研究院 2022-03-18 CN claimed
EP-2889370-A1 In vivo unnatural amino acid expression in the methylotrophic yeast Pichia pastoris The Scripps Research Institute (US) 2015-07-01 EP claimed
US-20140287464-A1 In Vivo Unnatural Amino Acid Expression in the Methylotrophic Yeast Pichia Pastoris SCRIPPS RESEARCH INST (US) 2014-09-25 US claimed
US-20140170704-A1 Production of Carrier-Peptide Conjugates Using Chemically Reactive Unnatural Amino Acids THE SCRIPPS RESEARCH INSTITUTE (US) 2014-06-19 US claimed
JP-2011527886-A 2011-11-10 JP claimed
US-20110014650-A1 IN VIVO UNNATURAL AMINO ACID EXPRESSION IN THE METHYLOTROPHIC YEAST PICHIA PASTORIS THE SCRIPPS RESEARCH INSTITUTE 2011-01-20 US claimed
EP-2231856-A2 IN VIVO UNNATURAL AMINO ACID EXPRESSION IN THE METHYLOTROPHIC YEAST PICHIA PASTORIS The Scripps Research Institute (US) 2010-09-29 EP claimed
US-20090197339-A1 In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris THE SCRIPPS RESEARCH INSTITUTE (US) 2009-08-06 US claimed
WO-2009075847-A2 IN VIVO UNNATURAL AMINO ACID EXPRESSION IN THE METHYLOTROPHIC YEAST PICHIA PASTORIS THE SCRIPPS RESEARCH INSTITUTE (US) 2009-06-18 WO claimed
US-20090081669-A1 Fluorescent Assays Using Orthogonal tRNA - Aminoacyl Synthetase Pairs ENCODE BIO, INC. (US) 2009-03-26 US claimed
WO-2007090198-A2 FLUORESCENT ASSAYS USING ORTHOGONAL TRNA - AMINOACYL SYNTHETASE PAIRS ENCODE BIO, INC. (US) 2007-08-09 WO claimed
EP-4727592-A1 CONJUGATED MOLECULES Valink Therapeutics Ltd (GB) 2026-04-22 EP disclosed
EP-4725953-A1 SELF-ASSEMBLING PEPTIDES AND HYDROGELS Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2026-04-15 EP disclosed
EP-4720264-A1 AMINOACYL-TRNA SYNTHETASE SETS United Kingdom Research and Innovation (GB) 2026-04-08 EP disclosed
US-12551572-B2 Modified viral particles for gene therapy EUROPEAN MOLECULAR BIOLOGY LABORATORY (DE) 2026-02-17 US disclosed
US-5460943-A Projecting monochromatic light to a sample, measuring the fluorescence intensity emitted by 4-methylumbelliferone which is converted by the enzyme from the substrate TOSOH CORPORATION (JP) 1995-10-24 US disclosed
CN-1100200-A Capillary electrophoretic sampling device without electric discrimination CHEMSTRY INST CHINESE ACADEMY (CN) 1995-03-15 CN disclosed
EP-0521636-A1 Method of assay of enzymatic activity and apparatus therefor TOSOH CORPORATION (JP) 1993-01-07 EP disclosed
US-4540548-A Method of detecting fluorescent materials and apparatus for their detection YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1985-09-10 US disclosed
US-4419452-A Method of detecting fluorescent materials and apparatus for their detection YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1983-12-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12551572-B2 Modified viral particles for gene therapy SMCHD1, SMC1A, TIMCC F2 2929/4885PRSS1 2477/4885PRSS2 4075/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.