SCHEMBL8674451

SCHEMBL8674451

CC(C)c1cc(-c2ccccc2)cc(C(C)C)c1C(C)C

nearest known ligand 0.44

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
ALDH1A1 P00352 1/20 0.41
KDM4E B2RXH2 1/20 0.38
HTT P42858 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
GABRA1 P14867 2/20 0.38
GABRB2 P47870 1/20 0.38
AHR P35869 1/20 0.37
HSP90AA1 P07900 1/20 0.37
PTGS2 P35354 1/20 0.36
ABCB1 P08183 1/20 0.36
GABRB1 P18505 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13799259 0.86 AKR1C2 (0.39) CA1CA2ALDH1A1KDM4EHTT
SCHEMBL10884746 0.83 CDC25A (0.39) CA1CA2HTTSMN1; SMN2GABRA1
SCHEMBL22431501 0.82 CA1 (0.44) CA1CA2ALDH1A1KDM4EHTT
SCHEMBL28922097 0.80 CA1 (0.43) CA1CA2ALDH1A1GABRA1GABRB2
SCHEMBL22408555 0.80 CA1 (0.43) CA1CA2ALDH1A1KDM4EGABRA1
SCHEMBL24757582 0.80 CA1 (0.74) CA1CA2ALDH1A1HTTGABRA1
SCHEMBL1491936 0.80 CA1 (0.43) CA1CA2ALDH1A1KDM4EHTT
SCHEMBL38652582 0.80 CRHBP (0.43) CA1CA2ALDH1A1KDM4EHTT
SCHEMBL25806605 0.80 CA1 (0.43) CA1CA2ALDH1A1KDM4EHTT
SCHEMBL24268972 0.80 CA1 (0.43) CA1CA2ALDH1A1GABRA1GABRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5847040-A Lower alkyl biphenyls as plasticizers for polyurethane KOCH INDUSTRIES, INC. (US) 1998-12-08 US disclosed
US-5696184-A EPOXY POLYMER CONTAINING DIISOPROPYLBIPHENYL AND/OR TRIISOPROPYLBIPHENYL; INCREASED FLEXIBILITY AND TOUGHNESS KOCH INDUSTRIES, INC. (US) 1997-12-09 US disclosed
US-5489646-A CAN USE HIGH LOAD LEVELS KOCH INDUSTRIES, INC. (US) 1996-02-06 US disclosed